Fig. 2

CCN3 expression in non-cancerous hepatic tissues correlates with cirrhosis. CCN3 expression in non-cancerous hepatic tissues obtained from 186 HCC patients is higher among patients with cirrhosis (a, b). CCN3 mRNA levels are upregulated in HCC patients with cirrhosis (c). CCN3 mRNA levels are increased in patients with cirrhosis according to gradient level (d). Western blotting shows that CCN3 levels are increased by LX2 in activated LO2 cells (e). ELISA shows that CCN3 expression is increased in activated LO2 cells exposed to CM compared with wild-type LO2 cells (f)