Table 2 Subgourp analyses of EFS on TET2 mutation
Variables | Number of studies, heterogeneity I2%, p | Pooled HRs(95% CI), P value | Interaction(p) | |
|---|---|---|---|---|
Year | 2016 | 1 | 3.430[1.479–7.955], P = 0.004 | 0.096 |
2015 | 3(74.8), P = 0.019 | 1.320[0.911–1.913], P = 0.142 | ||
2014 | 1 | 0.800[0.327–1.955], P = 0.624 | ||
2012 | 2(1.7), P = 0.313 | 1.613[1.217–2.138], P = 0.001 | ||
2011 | 1 | 1.320[0.982–1.774], P = 0.066 | ||
2010 | 1 | 3.970[1.140–13.826], P = 0.030 | ||
Data type | Multivariate | 3(76.4), P = 0.014 | 1.284[0.891–1.850], P = 0.181 | 0.110 |
Calculated from K-M curves | 5(26.2), P = 0.247 | 1.473[1.209–1.794], P < 0.001 | ||
univariate | 1 | 3.430[1.479–7.955], P = 0.004 | ||
Region | America | 2(83.0), P = 0.015 | 1.479[1.117–1.959], P = 0.006 | 0.413 |
Europe | 4(44.1), P = 0.147 | 1.580[1.215–2.055], P = 0.001 | ||
Asia | 2(76.4), P = 0.040 | 1.934[1.020–3.667], P = 0.043 | ||
other | 1 | 1.076[0.688–1.682], P = 0.748 | ||
Cohort | AML | 2(79.4), P = 0.028 | 1.669[1.189–2.344], P = 0.003 | 0.444 |
CN-AML | 5(47.5), P = 0.106 | 1.377[1.120–1.692], P = 0.002 | ||
Others | 2(76.4), P = 0.040 | 1.934[1.020–3.667], P = 0.043 | ||
Detection methods | Direct sequencing | 6(13.1), P = 0.331 | 1.283[1.058–1.556], P = 0.011 | 0.002 |
Next-generation sequencing | 3(38.3), P = 0.198 | 2.418[1.691–3.459], P < 0.001 | ||