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Table 3 Association of the T cell activation status and mortality of breast cancer stratified by the BRCA1 expression level

From: BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer

Stratification   Death
Variable Variable HRa 95% CIb p-value
Low BRCA1 T cell activation
 Exhaustion 1.00   
 Intermediate 0.47 0.28–0.80 0.006
 Activation 0.43 0.20–0.93 0.031
 p-trend   0.011  
 Age (per 5 years) 1.15 1.05–1.27 0.004
 Disease Stage 2.78 1.89–4.10 < 0.0001
Histological type
 Ductal 1.00   
 Lobular 0.54 0.29–1.00 0.048
 Mix 0.81 0.29–2.28 0.683
 Other 2.36 0.92–6.03 0.074
High BRCA1 T cell activation
 Exhaustion 1.00   
 Intermediate 1.47 0.85–2.55 0.174
 Activation 0.53 0.20–1.43 0.211
 p-trend   0.640  
 Age (per 5 years) 1.23 1.13–1.35 < 0.0001
 Disease Stage 2.07 1.45–2.96 < 0.0001
Histological type
 Ductal 1.00   
 Lobular 0.77 0.39–1.52 0.448
 Mix 0.68 0.25–1.87 0.450
 Other 2.79 1.09–7.13 0.032
P-value for the interaction between BRCA1 level and T cell activation   0.009  
  1. aHR: adjusted hazard ratio, which was obtained from a multivariate Cox proportional hazards regression model
  2. bCI confidence interval