Fig. 5

Upregulation of hsa_circ_0005379 attenuates the ability of OSCC cells to induce HUVEC cell migration and angiogenesis formation. a, b HUVEC cells were co-cultured with two kinds of conditioned medium (a) or SCC25 and CAL27 cells transduced with mock control or lentivirus expressing hsa_circ_0005379 (b). Data are presented as means ± SEM of three independent experiments. Student’s t-test, **P < 0.01, ***P < 0.001. Scale bar, 20 μm. c HUVEC cells were treated with or without conditioned medium for 12 h. Capillary-like tubes were visualized by phase contrast inverted microscopy and calculated