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Fig. 4 | BMC Cancer

Fig. 4

From: Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway

Fig. 4

Upregulation of hsa_circ_0005379 inhibits OSCC cell migration and invasion. a, b Wound healing assays were performed on (a) SCC25 and (b) CAL27 cells transduced with mock control or lentivirus expressing hsa_circ_0005379. The scratch area was measured at 0 and 48 h, and the percentage of closure at 48 h was calculated. c, d A Transwell assay was performed to quantify the migration and invasion ability of SCC25 and CAL27 cells transduced with mock control or lentivirus expressing hsa_circ_0005379. c Cells were seeded into the upper chamber (uncoated). After 24 h, those that crossed to the lower chamber were imaged and quantified. d Cells were seeded into the upper, Matrigel-coated chamber. After 48 h, cells that passed across the coated chamber were imaged and quantified. Data are presented as means ± SEM of three independent experiments. Student’s t-test, ***P < 0.001. Scale bar, 20 μm

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