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Fig. 3 | BMC Cancer

Fig. 3

From: Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

Fig. 3

Salinomycin triggers ER stress. a. Western blotting analyzed BIP, CHOP, Caspase 12 and ATF4 expression, and PERK and eIF2a phosphorylation in PC-3 cells treated with indicated concentration of salinomycin or DMSO as control (CON). b. The histogram shows fold protein expression normalized to control (ImageJ quantification of blots density from A. was performed, with three independent replicates.*P < 0.05 vs. control). c. The expression of BIP and CHOP in PC-3 cells treated as A. were measured by immunofluorescence. Scale bars, 10 μm. d. Representative immunofluorescence images of PC-3 cells transfected with pDsRed-ER and then treated with salinomycin. Scale bars, 10 μm. e. Transmission electron microscopy to show salinomycin-treated PC-3 cells. Scale bars, 1 μm

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