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Table 3 Sub-group analysis of LR rate of radiotherapy + surgery

From: Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Characteristic No. of studies Recurrence rate (95%CI) Heterogeneity
p I2 (%)
Study size
  < 20 11 0.07(0.00–0.21) 0.08 40.5
  ≥ 20 6 0.11(0.00–0.30) < 0.01 94.9
Follow-up
  < 5 yrs 11 0.10(0.00–0.34) < 0.01 82.9
  ≥ 5 yrs 6 0.06(0.00–0.25) < 0.01 87.0
Surgery type
 BCS ≥ 60% 8 0.11(0.00–0.31) < 0.01 88.1
 BCS < 60% 9 0.06(0.00–0.20) < 0.01 65.3
Age
  < 45 11 0.01(0.00–0.04) 0.36 8.6
  ≥ 45 6 0.22(0.04–0.48) < 0.01 92.6
Tumor size
  < 5 cm 5 0.18(0.02–0.42) < 0.01 92.3
  ≥ 5 cm 10 0.01(0.00–0.03) 0.38 6.3
Histologic Type
 Bo + M 8 0.10(0.05–0.28) < 0.01 93.2
 Malignant 9 0.06(0.00–0.20) 0.13 35.5
Margin
  > 1 cm ≥ 50% 4 0.01(0.00–0.15) 0.08 55.5
  > 1 cm < 50% 3 0.08(0.00–0.27) 0.12 53.4
 Positive ≥10% 6 0.10(0.05–0.27) 0.04 57.4
 Positive < 10% 3 0.05(0.00–0.45) < 0.01 95.0
  1. LR local recurrence, BCS Breast conserving surgery, Bo Borderline, M Malignant