Table 3 Sub-group analysis of LR rate of radiotherapy + surgery
Characteristic | No. of studies | Recurrence rate (95%CI) | Heterogeneity | |
|---|---|---|---|---|
p | I2 (%) | |||
Study size | ||||
  < 20 | 11 | 0.07(0.00–0.21) | 0.08 | 40.5 |
  ≥ 20 | 6 | 0.11(0.00–0.30) | < 0.01 | 94.9 |
Follow-up | ||||
  < 5 yrs | 11 | 0.10(0.00–0.34) | < 0.01 | 82.9 |
  ≥ 5 yrs | 6 | 0.06(0.00–0.25) | < 0.01 | 87.0 |
Surgery type | ||||
 BCS ≥ 60% | 8 | 0.11(0.00–0.31) | < 0.01 | 88.1 |
 BCS < 60% | 9 | 0.06(0.00–0.20) | < 0.01 | 65.3 |
Age | ||||
  < 45 | 11 | 0.01(0.00–0.04) | 0.36 | 8.6 |
  ≥ 45 | 6 | 0.22(0.04–0.48) | < 0.01 | 92.6 |
Tumor size | ||||
  < 5 cm | 5 | 0.18(0.02–0.42) | < 0.01 | 92.3 |
  ≥ 5 cm | 10 | 0.01(0.00–0.03) | 0.38 | 6.3 |
Histologic Type | ||||
 Bo + M | 8 | 0.10(0.05–0.28) | < 0.01 | 93.2 |
 Malignant | 9 | 0.06(0.00–0.20) | 0.13 | 35.5 |
Margin | ||||
  > 1 cm ≥ 50% | 4 | 0.01(0.00–0.15) | 0.08 | 55.5 |
  > 1 cm < 50% | 3 | 0.08(0.00–0.27) | 0.12 | 53.4 |
 Positive ≥10% | 6 | 0.10(0.05–0.27) | 0.04 | 57.4 |
 Positive < 10% | 3 | 0.05(0.00–0.45) | < 0.01 | 95.0 |