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Table 4 Multivariate analysis of PFS and OS in paired patients (N = 83)

From: Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma

  Cox’s regression for PFS Cox’s regression for OS
HR 95% Cl P value PA HR 95% Cl P value PA
ISUP
  ≥ 3 vs < 3 2.18 0.89–5.31 0.09 0.546 12.1 0.99–147.1 0.05 0.576
Nephrectomy
 Yes vs No      0.03 0.004–0.25 0.001 0.525
IMDC     0.615     0.618
 Low Ref. Ref. 0.04   Ref. Ref. 0.17  
 Intermediate 1.12 0.5–2.51 0.78   1.21 0.35–4.18 0.8  
 High 2.54 1.08–5.97 0.03   2.71 0.76–9.58 0.12  
Laboratory parameters
 WBC      1.02 1.01–1.04 0.002 0.624
 Na      0.93 0.82–1.06 0.26 0.556
PD-L1 positive (P)a      0.98 0.35–2.77 0.97 0.583
Cox model without PD-L1         0.754
Cox model with PD-L1         0.757
  1. aP, Primary tumor
  2. Abbreviations: ISUP International Society of Urological Pathology, IMDC International Metastatic Renal-Cell Carcinoma Database Consortium
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