Skip to main content

Advertisement

Fig. 5 | BMC Cancer

Fig. 5

From: Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

Fig. 5

Purifying selection on the nonsense mutations that create stop codons in coding region. a Relative position of the nonsense variants in cancer-related genes and other genes. P-value was calculated using Wilcoxon rank sum test. b Comparison between the nonsense/syn ratios in cancer-related genes and other genes. P-value was calculated using Fisher’s exact test. c A diagram illustrating the effects of double-mutation within a codon. Quite a lot of double-mutations result in a stop codon in CDS. d Comparison between the double-mutation/syn ratios in cancer-related genes and other genes. P-value was calculated using Fisher’s exact test. e Relative position of the double-mutations that create stop codons cancer-related genes and other genes. “onco” denotes cancer-related genes; “non-onco” denotes other genes

Back to article page