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Table 2 List of significant pathways identified through PANTHER database (Protein ANalysis THrough Evolutionary Relationships) with the protein carried by extracellular vesicles circulating in the plasma of HNSCC patients, according to CRT response (CR complete responders or NR non-responders)

From: A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma

Related Pathway

Raw p-value

FDR q-value

Related Molecules

NR EVs (n of proteins = 67)

 Insulin/ MAP kinase cascade

1.85E-04

7.54E-03

IGFR1, RAF1, IRS1

 PI3 kinase

7.62E-04

1.38E-02

NOS3, CCND1, IRS1

 Interleukin signaling

1.95E-04

6.35E-03

NOS3, RAF1, IRS1, STAT5

 VEGF signaling

1.37E-03

2.24E-02

VEGFA, NOS3, RAF1

 EGF receptor signaling

8.47E-05

6.90E-03

YWHAB, RAF1, ERBB4, GAB1, STAT5

 Alzheimer disease-presenilin

6.37E-04

1.30E-02

MMP1, CTNNA1, ERBB4, WNT1

 Angiogenesis

2.21E-04

6.01E-03

MMP1, CTNNA1, ERBB4, WNT1

CCKR signaling map

2.27E-04

5.29E-03

ITGB1, YWHAB, RAF1, IRS1, CCND1

 Gonadotropin-releasing

1.02E-04 5.57E-03

ITGB1, MT-CO2, INHA, RAF1, IGFR1, IRS1

CR EVs (n of proteins = 32)

 FAS signaling p53 signaling

1.63E-03

4.43E-02

CAD, CASP3

4.76E-04

1.94E-02

TP73, BAX, HDAC1

 Apoptosis signaling

5.19E-05

2.82E-03

BAX, IKBKB, CASP3, CREB1

 CCKR signaling map

1.10E-05

8.99E-04

ODC1, SNAI1, BAX, CREB1, CASP3

 Huntington disease

1.88E-03

4.39E-02

TP73, BAX, CASP3

 Cadherin signaling

2.39E-03

4.88E-02

CDH3, EGFR

 Gonadotropin-releasing

6.61E-04

2.15E-02

CREB1, EGFR, INS, SLC2A1