From: Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome
Variable | univariate | multivariate | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Gender | ||||||
female | 1 | 1 | ||||
male | 2.7 | 1.2–5.9 | *0.013 | 1.3 | 0.5–3.8 | 0.57 |
Localization | ||||||
lung | 1 | 1 | ||||
non-lung | 1.1 | 0.6–2.3 | 0.74 | 1.4 | 0.6–3.4 | 0.46 |
Grade | ||||||
NET | 1 | 1 | ||||
NEC | 2.7 | 1.2–6.2 | *0.022 | 4.2 | 1.1–16.1 | *0.038 |
Ki-67 | ||||||
< 55% | 1 | 1 | ||||
> 55% | 1.5 | 0.6–3.4 | 0.39 | 0.9 | 0.3–2.8 | 0.94 |
Age | ||||||
< 60 | 1 | 1 | ||||
≥ 60 | 2.1 | 1.0–4.3 | *0.041 | 3.0 | 1.2–7.5 | *0.016 |
Metastases | ||||||
LN +/− liver | 1 | 1 | ||||
LN +/− liver + | 0.5 | 0.2–1.2 | 0.10 | 1.5 | 0.5–4.6 | 0.47 |
other | ||||||
No. of BM | ||||||
≤ 2 | 1 | 1 | ||||
> 2 | 0.9 | 0.4–2.0 | 0.79 | 0.7 | 0.3–1.8 | 0.51 |