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Table 2 Univariate and multivariate analysis for prognostic indicators

From: Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome

Variable univariate multivariate
HR 95% CI p-value HR 95% CI p-value
Gender
 female 1    1   
 male 2.7 1.2–5.9 *0.013 1.3 0.5–3.8 0.57
Localization
 lung 1    1   
 non-lung 1.1 0.6–2.3 0.74 1.4 0.6–3.4 0.46
Grade
 NET 1    1   
 NEC 2.7 1.2–6.2 *0.022 4.2 1.1–16.1 *0.038
Ki-67
  < 55% 1    1   
  > 55% 1.5 0.6–3.4 0.39 0.9 0.3–2.8 0.94
Age
  < 60 1    1   
  ≥ 60 2.1 1.0–4.3 *0.041 3.0 1.2–7.5 *0.016
Metastases
 LN +/− liver 1    1   
 LN +/− liver + 0.5 0.2–1.2 0.10 1.5 0.5–4.6 0.47
 other       
No. of BM
  ≤ 2 1    1   
  > 2 0.9 0.4–2.0 0.79 0.7 0.3–1.8 0.51
  1. Abbreviations: NET neuroendocrine tumors; NEC neuroendocrine carcinomas; BM brain metastases; HR hazard ratio; CI confidence interval; LN lymph nodes
  2. *P<0.05