Fig. 1
From: Functional role of SGK3 in PI3K/Pten driven liver tumor development
Overexpression of PIK3CA E545K or H1047R mutant induces hepatic steatosis in Sgk3 knockout mice. a Gross image of livers from Sgk3 wild-type (Sgk3+/+) and Sgk3 knockout (Sgk3−/−) mice injected with PIK3CA(E545K) and PIK3CA(H1047R) constructs. Mice were sacrificed 4 weeks post hydrodynamic injection. b H&E staining of PIK3CA(E545K) and PIK3CA(H1047R) mouse livers; magnifications: 40x (scale bar = 500 μm) and 100x (scale bar = 200 μm). c ORO staining, magnifications: 200x. Abbreviation: H&E, haematoxylin and eosin staining; ORO, Oil Red O staining