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Fig. 4 | BMC Cancer

Fig. 4

From: Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles

Fig. 4

Heterogeneity index of MDA-MB 231 clones inferred from methylation profile obtained by MS-MLPA. a. Heat map showing the methylation status of 60 CpG sites (in columns) on MDA-MB 231 initial population and 5 clones (in rows). A color gradient from blue-white-red is used to represent low to high values of methylation (from 0 to 1). b. HI calculated for the MDA-MB 231 initial population (IP) and 5 clones represented in box plot graph. c. Scatter graph showing the methylation divergence from IP of 60 CpG sites for all the clones. Divergence was defined as the difference of methylation value of the CpG sites between the clones and the initial population (∆ = Clone - IP). Green bars show the CpGs methylated in the IP. d. Scatter graph showing the individual divergence of two clones. G8 clone (blue dots) diverged mostly increasing the methylation while C7 clone (red dots) diverged mostly decreasing the methylation of CpG sites

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