Skip to main content

Advertisement

Table 3 Immunohistochemical staining results of 15 candidate proteins

From: Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis

Gene Protein name IHC: Small cohort group IHC: Large cohort group
PHC DCC P-value PHC DCC P-value
Putatively PHC specific by MS
 ANXA10 Annexin A10 7/12 (58%) 1/12 (8.3%) 0.0272 59/72 (81.9%) 36/74 (48.7%) 0.0001
 KRT17 Cytokeratin-17 10/12 (83.3%) 6/12 (50%) 0.193 55/72 (76.4%) 21/74 (28.4%) 0.0001
 FLNA Filamin A 1/12 (8.3%) 1/12 (8.3%) 1    
 S100A9 S100 A9 2/12 (16.7%) 1/12 (8.3%) 1    
 TMEM109 Transmembrane protein 109 9/12 (75%) 5/12 (42%) 0.214 48/72 (66.7%) 27/74 (35.4%) 0.0003
Putatively DCC specific by MS
 ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1 3/12 (25%) 7/12 (58%) 0.324 30/72 (41.7%) 45/74 (60.8%) 0.0310
 MAOA Amino oxidase A 6/12 (50%) 5/12 (42%) 1    
 PTMS Parathymosin 1/12 (8.3%) 9/12 (75%) 0.0028 20/72 (27.8%) 45/74 (60.8%) 0.0001
 FGA Fibrinogen alpha chain 0/12 (0%) 2/12 (16.7%) 0.478    
 SLC12A2 Solute carrier family 12 member 2 5/12 (42%) 7/12 (58%) 0.684    
 CAT Catalase 2/12 (16.7%) 4/12 (33.3%) 0.640    
 PABPC1 Polyadenylate-binding protein 1 5/12 (42%) 6/12 (50%) 1    
 CPS1 Carbamoyl-phosphate synthase 1 1/12 (8.3%) 4/12 (33.3%) 0.312    
 CCT6A T-complex protein 1 subunit zeta 6/12 (50%) 7/12 (58%) 1    
 EIF4A1 Eukaryotic initiation factor 4A-1 4/12 (33.3%) 5/12 (42%) 1    
  1. MS Mass spectrometry, IHC Immunohistochemistry, PHC Pancreatic head cancer, DCC Distal cholangiocarcinoma