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Table 3 Immunohistochemical staining results of 15 candidate proteins

From: Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis

Gene

Protein name

IHC: Small cohort group

IHC: Large cohort group

PHC

DCC

P-value

PHC

DCC

P-value

Putatively PHC specific by MS

 ANXA10

Annexin A10

7/12 (58%)

1/12 (8.3%)

0.0272

59/72 (81.9%)

36/74 (48.7%)

0.0001

 KRT17

Cytokeratin-17

10/12 (83.3%)

6/12 (50%)

0.193

55/72 (76.4%)

21/74 (28.4%)

0.0001

 FLNA

Filamin A

1/12 (8.3%)

1/12 (8.3%)

1

   

 S100A9

S100 A9

2/12 (16.7%)

1/12 (8.3%)

1

   

 TMEM109

Transmembrane protein 109

9/12 (75%)

5/12 (42%)

0.214

48/72 (66.7%)

27/74 (35.4%)

0.0003

Putatively DCC specific by MS

 ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1

3/12 (25%)

7/12 (58%)

0.324

30/72 (41.7%)

45/74 (60.8%)

0.0310

 MAOA

Amino oxidase A

6/12 (50%)

5/12 (42%)

1

   

 PTMS

Parathymosin

1/12 (8.3%)

9/12 (75%)

0.0028

20/72 (27.8%)

45/74 (60.8%)

0.0001

 FGA

Fibrinogen alpha chain

0/12 (0%)

2/12 (16.7%)

0.478

   

 SLC12A2

Solute carrier family 12 member 2

5/12 (42%)

7/12 (58%)

0.684

   

 CAT

Catalase

2/12 (16.7%)

4/12 (33.3%)

0.640

   

 PABPC1

Polyadenylate-binding protein 1

5/12 (42%)

6/12 (50%)

1

   

 CPS1

Carbamoyl-phosphate synthase 1

1/12 (8.3%)

4/12 (33.3%)

0.312

   

 CCT6A

T-complex protein 1 subunit zeta

6/12 (50%)

7/12 (58%)

1

   

 EIF4A1

Eukaryotic initiation factor 4A-1

4/12 (33.3%)

5/12 (42%)

1

   
  1. MS Mass spectrometry, IHC Immunohistochemistry, PHC Pancreatic head cancer, DCC Distal cholangiocarcinoma