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Table 3 Immunohistochemical staining results of 15 candidate proteins
| Gene | Protein name | IHC: Small cohort group | IHC: Large cohort group | ||||
|---|---|---|---|---|---|---|---|
| PHC | DCC | P-value | PHC | DCC | P-value | ||
| Putatively PHC specific by MS | |||||||
| ANXA10 | Annexin A10 | 7/12 (58%) | 1/12 (8.3%) | 0.0272 | 59/72 (81.9%) | 36/74 (48.7%) | 0.0001 |
| KRT17 | Cytokeratin-17 | 10/12 (83.3%) | 6/12 (50%) | 0.193 | 55/72 (76.4%) | 21/74 (28.4%) | 0.0001 |
| FLNA | Filamin A | 1/12 (8.3%) | 1/12 (8.3%) | 1 | |||
| S100A9 | S100 A9 | 2/12 (16.7%) | 1/12 (8.3%) | 1 | |||
| TMEM109 | Transmembrane protein 109 | 9/12 (75%) | 5/12 (42%) | 0.214 | 48/72 (66.7%) | 27/74 (35.4%) | 0.0003 |
| Putatively DCC specific by MS | |||||||
| ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | 3/12 (25%) | 7/12 (58%) | 0.324 | 30/72 (41.7%) | 45/74 (60.8%) | 0.0310 |
| MAOA | Amino oxidase A | 6/12 (50%) | 5/12 (42%) | 1 | |||
| PTMS | Parathymosin | 1/12 (8.3%) | 9/12 (75%) | 0.0028 | 20/72 (27.8%) | 45/74 (60.8%) | 0.0001 |
| FGA | Fibrinogen alpha chain | 0/12 (0%) | 2/12 (16.7%) | 0.478 | |||
| SLC12A2 | Solute carrier family 12 member 2 | 5/12 (42%) | 7/12 (58%) | 0.684 | |||
| CAT | Catalase | 2/12 (16.7%) | 4/12 (33.3%) | 0.640 | |||
| PABPC1 | Polyadenylate-binding protein 1 | 5/12 (42%) | 6/12 (50%) | 1 | |||
| CPS1 | Carbamoyl-phosphate synthase 1 | 1/12 (8.3%) | 4/12 (33.3%) | 0.312 | |||
| CCT6A | T-complex protein 1 subunit zeta | 6/12 (50%) | 7/12 (58%) | 1 | |||
| EIF4A1 | Eukaryotic initiation factor 4A-1 | 4/12 (33.3%) | 5/12 (42%) | 1 | |||
