Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis

BMC Cancer

Table 2 Proteins identified in shotgun proteomics

Accession Number	Gene	Protein name	Spectral counting method				G-test
			Spectral count		Rsc	SpI	G-score	P-value
			PHC	DCC	Rsc	SpI	G-score	P-value
Up-regulated in PHC
Q9UJ72	ANXA10	Annexin A10	62	9	−2.49	0.70	39.2	< 0.01
Q04695	KRT17	Cytokeratin-17	119	20	−2.37	0.62	68.8	< 0.01
P21333	FLNA	Filamin A	124	21	−2.36	0.66	71.4	< 0.01
P06702	S100A9	S100 A9	39	6	−2.36	0.63	23.7	< 0.01
Q9BVC6	TMEM109	Transmembrane protein 109	16	2	−2.27	0.66	10.8	< 0.01
Up-regulated in DCC
P05026	ATP1B1	Sodium/potassium-transporting ATPase subunit beta-1	0	15	3.84	−0.88	21.6	< 0.01
P21397	MAOA	Amino oxidase A	2	24	3.10	−0.70	23.7	< 0.01
P20962	PTMS	Parathymosin	0	7	2.86	−0.63	9.71	< 0.01
P02671	FGA	Fibrinogen alpha chain	2	17	2.63	−0.79	14.7	< 0.01
P55011	SLC12A2	Solute carrier family 12 member 2	0	5	2.46	−0.63	6.75	< 0.01
P04040	CAT	Catalase	2	14	2.37	−0.76	11.0	< 0.01
P11940	PABPC1	Polyadenylate-binding protein 1	1	9	2.33	−0.91	7.78	< 0.01
P31327	CPS1	Carbamoyl-phosphate synthase 1	23	104	2.27	−0.61	64.0	< 0.01
P40227	CCT6A	T-complex protein 1 subunit zeta	3	15	2.07	−0.62	9.68	< 0.01
P60842	EIF4A1	Eukaryotic initiation factor 4A-1	9	28	1.65	−0.73	12.0	< 0.01

Rsc Protein ratio from spectral counting, SpI Spectral index, PHC Pancreatic head cancer, DCC Distal cholangiocarcinoma

ISSN: 1471-2407