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Table 3 List of 87 found as differentially abundant after paired comparison of NAF samples from breast cancer patients

From: Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow

Accession number

Stouffer’s p-valuea

# of unique peptidesb

Sequence coveragec

Protein descriptiond

P01023

« 0.05

171

69%

Alpha-2-macroglobulin

P04114

« 0.05

233

48%

Apolipoprotein B-100

P02768

2.89E-15

535

92%

Serum albumin

P02751

5.00E-14

116

51%

Fibronectin

P00450

4.61E-10

138

66%

Ceruloplasmin

P01008

7.85E-10

49

56%

Antithrombin-III

P01024

5.75E-09

293

79%

Complement C3

Q14624

7.30E-08

66

53%

Inter-alpha-trypsin inhibitor heavy chain H4

P02647

7.97E-08

65

79%

Apolipoprotein A-I

P69905

1.77E-06

80

89%

Hemoglobin subunit alpha

P01031

1.86E-06

64

45%

Complement C5

P02787

5.85E-06

233

79%

Serotransferrin

P19823

1.72E-05

40

39%

Inter-alpha-trypsin inhibitor heavy chain H2

P04075

2.11E-05

20

56%

Fructose-bisphosphate aldolase A

P06733

2.772E-05

22

45%

Alpha-enolase

P00751

3.486E-05

62

53%

Complement factor B

P02763

5.823E-05

23

33%

Alpha-1-acid glycoprotein 1

P04217

6.358E-05

39

59%

Alpha-1B-glycoprotein

O43707

8.867E-05

25

32%

Alpha-actinin-4

P02743

8.875E-05

7

28%

Serum amyloid P-component

P63104

0.0001746

17

49%

14–3-3 protein zeta/delta

P08603

0.00018

78

51%

Complement factor H

P62937

0.0001889

7

32%

Peptidyl-prolyl cis-trans isomerase A

P01859

0.00026

41

41%

Immunoglobulin heavy constant gamma 2

P02748

0.0002745

33

57%

Complement component C9

P05109

0.000281

10

65%

Protein S100-A8

P01871

0.000404

76

70%

Immunoglobulin heavy constant mu

P04003

0.00059

49

60%

C4b-binding protein alpha chain

P51884

0.0007103

10

28%

Lumican

P02671

0.0007129

85

53%

Fibrinogen alpha chain

P35579

0.0008537

27

18%

Myosin-9

P00558

0.0009974

13

28%

Phosphoglycerate kinase 1

P62258

0.0012498

9

36%

14–3-3 protein epsilon

P37802

0.0014134

11

42%

Transgelin-2

P01857

0.0014264

44

24%

Immunoglobulin heavy constant gamma 1

P19827

0.0014914

26

33%

Inter-alpha-trypsin inhibitor heavy chain H1

P02652

0.0016813

44

71%

Apolipoprotein A-II

P06744

0.0020099

11

19%

Glucose-6-phosphate isomerase

P31946

0.0020626

11

43%

14–3-3 protein beta/alpha

P60174

0.0023591

21

63%

Triosephosphate isomerase

P02656

0.0023949

7

56%

Apolipoprotein C-III

P01619

0.0024969

13

42%

Immunoglobulin kappa variable 3–20

P13671

0.0031513

34

44%

Complement component C6

P02766

0.0035804

27

69%

Transthyretin

P00338

0.003773

18

45%

L-lactate dehydrogenase A chain

P13639

0.0038429

20

32%

Elongation factor 2

P46940

0.0040271

24

22%

Ras GTPase-activating-like protein IQGAP1

P23528

0.004225

10

40%

Cofilin-1

P00738

0.0043519

57

52%

Haptoglobin

P29401

0.0044629

15

28%

Transketolase

P01019

0.0046976

26

37%

Angiotensinogen

P02679

0.0048135

76

68%

Fibrinogen gamma chain

P43652

0.0048791

33

44%

Afamin

P04406

0.00503

19

55%

Glyceraldehyde-3-phosphate dehydrogenase

Q13228

0.0052836

10

27%

Methanethiol oxidase

P06702

0.005869

16

82%

Protein S100-A9

P05546

0.0059243

21

46%

Heparin cofactor 2

P02794

0.0069928

15

40%

Ferritin heavy chain

O14791

0.0071293

16

36%

Apolipoprotein L1

P04196

0.0102909

37

53%

Histidine-rich glycoprotein

P31151

0.0123024

6

32%

Protein S100-A7

P01817

0.0127189

13

52%

Immunoglobulin heavy variable 2–5

Q99497

0.0143139

6

34%

Protein/nucleic acid deglycase DJ-1

P61981

0.0148811

7

36%

14–3-3 protein gamma

P14618

0.0158523

31

51%

Pyruvate kinase PKM

P01042

0.0159025

35

41%

Kininogen-1

Q96PD5

0.0166293

30

58%

N-acetylmuramoyl-L-alanine amidase

P02792

0.0180461

20

66%

Ferritin light chain

P02750

0.0183273

18

44%

Leucine-rich alpha-2-glycoprotein

P00734

0.0186734

46

54%

Prothrombin

P15311

0.0199674

21

25%

Ezrin

P08758

0.0203289

25

60%

Annexin A5

P32119

0.0204951

13

57%

Peroxiredoxin-2

P02747

0.0210238

6

44%

Complement C1q subcomponent subunit C

P04083

0.0212142

14

41%

Annexin A1

P07900

0.0226553

6

11%

Heat shock protein HSP 90-alpha

P04040

0.022793

33

52%

Catalase

P05543

0.0228794

8

22%

Thyroxine-binding globulin

P08582

0.9849647

41

54%

Melanotransferrin

P19835

0.9915665

74

48%

Bile salt-activated lipase

P08294

0.9923999

19

62%

Extracellular superoxide dismutase [Cu-Zn]

P15144

0.9945681

100

53%

Aminopeptidase N

Q86UK0

0.9954266

16

5%

ATP-binding cassette sub-family A member 12

P12273

0.9980643

104

77%

Prolactin-inducible protein

P22897

0.9986817

81

45%

Macrophage mannose receptor 1

P05090

0.9998501

105

93%

Apolipoprotein D

P02788

1

422

89%

Lactotransferrin

  1. aThe Stouffer’s p-value obtained from the independent peptide p-values mapping to the respective protein
  2. bThe # of peptides refers to the number of peptides considered for the calculation of the Stouffer’s p-value
  3. cThe Sequence coverage was calculated considering all peptides mapping to the respective protein
  4. dThe Protein description reflects the UniProt description
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BMC Cancer

ISSN: 1471-2407

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