|
Gender
|
|
Male (n = 35)
|
1
|
p = 0.2
|
1
|
p = 0.5
|
|
Female (n = 11)
|
0.5 [0.1–1.6]
| |
0.7 [0.3–1.9]
| |
|
Histology
|
|
Non squamous (n = 24)
|
1
|
p = 0.3
|
1
|
p = 0.9
|
|
Squamous (n = 22)
|
1.48 [0.6–3.2]
| |
0.9 [0.5–1.7]
| |
|
Age
|
|
< 66 years (n = 23)
|
1
|
p = 0.4
|
1
|
p = 0.9
|
|
≥ 66 years (n = 23)
|
1.4 [0.5–3.7]
| |
0.9 [0.5–2]
| |
|
Period between irradiations
|
|
> 24 months (n = 20)
|
1
|
p = 0.8
|
1
|
p = 0.1
|
|
≤ 24 months (n = 25)
|
1.1 [0.4–2.9]
| |
1.8 [0.8–3.9]
| |
|
Missing value (n = 1)
| | | | |
|
> 12 months (n = 36)
|
1
|
p = 0.8
|
1
|
p = 0.5
|
|
≤ 12 months (n = 9)
|
1.09 [0.3–3.6]
| |
1.3 [0.5–3.5]
| |
|
Missing value (n = 1)
| | | | |
|
Dose of reirradiation
|
|
BED > 130 Gy (n = 28)
|
1
|
p = 0.9
|
1
|
p = 0.09
|
|
BED ≤130 Gy (n = 18)
|
0.9 [0.3–2.5]
| |
1.8 [0.9–3.9]
| |
|
BEDmin ≤50 Gy (n = 22)
|
1
|
p = 0.16
|
1
|
p = 0.06
|
|
BEDmin > 50 Gy (n = 23)
|
0.5 [0.2–1.3]
| |
0.5 [0.2–1.05]
| |
|
SABR duration
|
|
≥ 6 days (n = 25)
|
1
|
p = 0.4
|
1
|
p = 0.7
|
|
< 6 days (n = 20)
|
1.5 [0.56–4.11]
| |
0.9 [0.4–1.8]
| |
|
Chemotherapy after reirradiation
|
|
Yes (n = 10)
|
1
| |
1
| |
|
No (n = 36)
|
1.6 [0.4–5.5]
|
p = 0.4
|
1.6 [0.7–3.9]
|
p = 0.2
|
|
Tumor size
|
|
< 33 mm (n = 22)
|
1
| |
1
| |
|
≥ 33 mm (n = 21)
|
1.58 [0.6–4.1]
|
p = 0.3
|
1.6 [0.8–3.5]
|
p = 0.18
|
|
Missing value (n = 3)
| | | | |
|
GTV Volume
|
|
< 13 mL (n = 22)
|
1
| |
1
| |
|
≥ 13 mL (n = 22)
|
1.49 [0.57–3.95]
|
p = 0.4
|
1.83 [0.87–3.82]
|
p = 0.10
|
|
Missing value (n = 2)
| | | | |
|
SABR duration
|
|
≥ 6 days (n = 25)
|
1
|
p = 0.4
|
1
|
p = 0.7
|
|
< 6 days (n = 21)
|
1.51 [0.56–4.1]
| |
0.87 [0.42–1.79]
| |
|
Number of fractions
|
|
≤ 3 (n = 16)
|
1
|
p = 0.09
|
1
|
p = 0.9
|
|
> 3 (n = 30)
|
2.85 [0.85–9.6]
| |
0.99 [0.47–2.1]
| |
|
Dose per fraction
|
|
> 12 (n = 23)
|
1
|
p = 0.8
|
1
|
p = 0.2
|
|
≤ 12 (n = 22)
|
0.93 [0.35–2.44]
| |
1.54 [0.74–3.21]
| |
|
Performans Status - ECOGa
|
|
1 (n = 11)
|
1
|
p = 0.7
|
1
|
p = 0.19
|
|
0 (n = 27)
|
0.78 [0.2–2.9]
| |
1.8 [0.7–4.4]
| |
|
Missing value (n = 8)
| | | | |
|
Location of relapse
|
|
Peripheral (n = 22) Central
|
1
|
p = 0.03
|
1
|
p = 0.9
|
|
(n = 24)
|
3.2 [1.1–9.5]
| |
0.9 [0.4–2.1]
| |
|
Primary stage (at first irradiation)
|
|
IIIA (n = 21)
|
1
|
p = 0.6
|
1
|
p = 0.11
|
|
IIIB (n = 25)
|
1.2 [0.5–3.2]
| |
1.8 [0.9–3.7]
| |
|
In-field relapse
|
|
No (n = 17)
|
1
|
p = 0.2
|
1
|
p = 0.2
|
|
Yes (n = 29)
|
2 [0.7–5.9]
| |
1.6 [0.7–3.6]
| |
|
In-field relapse and central tumors
|
|
No (n = 26)
|
1
|
p = 0.04
|
1
|
p = 0.8
|
|
Yes (n = 19)
|
2.8 [1.1–7.3]
| |
0.9 [0.4–1.9]
| |
|
Adjuvant chemotherapy
|
|
No (n = 36)
|
1
|
p = 0.4
|
1
|
p = 0.2
|
|
Yes (n = 10)
|
1.6 [0.5–5.5]
| |
1.6 [0.7–3.8]
| |
|
GTV coverage
|
|
< 95% (n = 22)
|
1
|
p = 0.1
|
1
|
p = 0.07
|
|
≥ 95% (n = 24)
|
0.45 [0.17–1.18]
| |
0.5 [0.2–1.06]
| |
|
PTV coverage
|
|
< 90% (n = 23)
|
1
|
p = 0.17
|
1
|
p = 0.04
|
|
≥ 90% (n = 23)
|
0.5 [0.19–1.32]
| |
0.4 [0.2–0.98]
| |
