Table 2 Predictive factors for tumor response
Variable | Complete or Partial Response | Stabilization or progression | p value (Chi Square) | Binary logistic regressionb | p-value |
|---|---|---|---|---|---|
Gender | |||||
Male (n = 35) | 60% | 40% | 0.4 | NI | |
Female (n = 11) | 72.7% | 27.3% | |||
Histology | |||||
Squamous (n = 22) | 59.1% | 40.9% | 0.6 | NI | |
Non squamous (n = 24) | 66.7% | 33.3% | |||
Age | |||||
< 66 years (n = 23) | 69.6% | 30.4% | 0.3 | NI | |
≥ 66 years (n = 23) | 56.5% | 43.5% | |||
Dose of reirradiation | |||||
BED ≤130 Gy (n = 18) | 50% | 50% | 0.14 | NI | |
BED > 130 Gy (n = 28) | 71.4% | 28.6% | |||
BEDmin ≤50 Gy (n = 22) | 54.5% | 45.5% | 0.3 | NI | |
BEDmin > 50 Gy (n = 23) | 69.6% | 30.4% | |||
Tumor size | |||||
≥ 33 mm (n = 21) | 42.9% | 57.1% | 0.008 | 1 | 0.04 |
< 33 mm (n = 22) | 81.8% | 18.2% | OR = 0.21 | ||
Missing value (n = 3) | [0.04–0.93] | ||||
GTV Volume | |||||
≥ 13 mL (n = 22) | 33.3% | 76.5% | 0.005 | NI | |
< 13 mL (n = 22) | 66.7% | 23.5% | |||
Missing value (n = 2) | |||||
SABR duration | |||||
≥ 6 days (n = 25) | 64% | 36% | 0.8 | NI | |
< 6 days (n = 21) | 61.9% | 38.1% | |||
Number of fractions | |||||
> 3 (n = 30) | 60% | 40% | 0.5 | NI | |
≤ 3 (n = 16) | 68.8% | 31.2% | |||
Dose per fraction | |||||
> 12 (n = 23) | 69.6% | 30.4% | 0.3 | NI | |
≤ 12 (n = 16) | 56.5% | 43.5% | |||
Performans Status ECOGa | |||||
0 (n = 27) | 70.4% | 29.6% | 0.9 | NI | |
1 (n = 11) | 72.7% | 27.3% | |||
Missing value (n = 8) | |||||
Location of relapse | |||||
Central (n = 24) | 50% | 50% | 0.06 | NI | |
Peripheral (n = 22) | 77.3% | 22.7% | |||
Primary stage (at first irradiation) | |||||
IIIA (n = 21) | 61.9% | 38.1% | 0.9 | NI | |
IIIB (n = 25) | 64% | 36% | |||
In-field relapse | |||||
Yes (n = 29) | 48.3% | 51.7% | 0.03 | 1 | 0.14 |
No (n = 17) | 82.4% | 17.6% | OR = 0.26 [0.04–1.6] | ||
In-field relapse and central tumors | |||||
Yes (n = 19) | 35.3% | 64.7% | 0.01 | NIc | |
No (n = 26) | 72.4% | 27.6% | |||
GTV coverage | |||||
< 95% (n = 22) | 50% | 50% | 0.07 | NI | |
≥ 95% (n = 24) | 75% | 25% | |||
PTV coverage | |||||
< 90% (n = 23) | 47.8% | 52.2% | p = 0.03 | 1 | 0.11 |
≥ 90% (n = 23) | 78.3% | 21.7% | OR = 3.2 [0.74–13.8] | ||