Fig. 4

Association between overexpression of Nodal and susceptibility to apoptosis in OCCCa and OEmCa. a Staining by hematoxylin and eosin (HE) and IHC for Nodal in OCCCa and OEmCa. Insets show the magnified views of the boxed areas, demonstrating typical apoptotic cells. Original magnification, × 200, × 400 (inset). b Left: number of apoptotic cells detected in HE sections of OCCCa (upper) and OEmCa (lower) between positive (P) (score≧ 1) and negative (N) Nodal categories (score = 0). The data shown are means ± SDs. Right: correlation between Nodal score and number of apoptotic cells in OCCCa (upper) and OEmCa (lower). c Staining by hematoxylin and eosin (HE) and IHC for the indicated proteins in OCCCa and OEmCa. Insets show the magnified views of the boxed areas. Original magnification, × 200, × 400 (inset). d IHC scores for the indicated proteins in a combination of endometriosis and OCCCa (left) or OEmCa (right). E1, endometriosis without carcinoma; E2, endometriosis with carcinoma; Ca, carcinoma. The data shown are means ± SDs