TY - JOUR AU - Furugaki, Koh AU - Mochizuki, Marie AU - Kohno, Mirei AU - Shu, Sei AU - Harada, Naoki AU - Yoshimura, Yasushi PY - 2019 DA - 2019/04/03 TI - Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion JO - BMC Cancer SP - 301 VL - 19 IS - 1 AB - Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1), occur in non-small cell lung cancers, and these oncogenic drivers are important biomarkers for targeted therapies. A useful technique to screen for these fusions is the detection of native carboxy-terminal (C-terminal) protein by immunohistochemistry; however, the effects of other genetic alterations on C-terminal expression is not fully understood. In this study, we evaluated whether C-terminal expression is specifically elevated by fusion with or without typical genetic alterations of lung cancer. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-019-5527-2 DO - 10.1186/s12885-019-5527-2 ID - Furugaki2019 ER -