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Fig. 1 | BMC Cancer

Fig. 1

From: Differentiating atypical lipomatous tumors from lipomas with magnetic resonance imaging: a comparison with MDM2 gene amplification status

Fig. 1

(a) Lipoma with equally large fat vacuoles, no atypia recognizable. (b) Corresponding fluorescence in situ hybridization (FISH) analysis MDM2 gene (disomy concerning MDM2, green: gen probe MDM2 region; red: centromere probe chromosome 12; two green and two red signals per cell means disomy, no amplification of the MDM2 locus = > lipoma). (c) atypical lipomatous tumors (ALT) with atypical stromal cells with nuclear hyperchromasia and size variations of fat vacuoles. (d) Corresponding fluorescence in situ hybridization (FISH) analysis MDM2 gene (Cluster-like signals in green means amplification of MDM2 locus, red signal marks the centromere probe chromosome 12 as a control = > ALT)

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BMC Cancer

ISSN: 1471-2407

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