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Table 1 Patients’ characteristic

From: It’s never too late - balance and endurance training improves functional performance, quality of life, and alleviates neuropathic symptoms in cancer survivors suffering from chemotherapy-induced peripheral neuropathy: results of a randomized controlled trial

  Intention-to-treat Per-protocol
All N = 41 IG vs. CG P IG N = 18 CG N = 19 All N = 37 IG vs. CG P
Age
 median (range) 62 (44 – 82) 0.025 70 (44 – 82) 60 (46 – 75) 63 (44 – 82) 0.026
Sex
 m:f N (%) 11 (27): 30 (73)   4 (22): 14 (78) 7 (37): 12 (63) 11 (30): 26 (70)  
BMI
 median (range) 25 (19 – 42) 0.375 25 (19 – 42) 24 (21 – 31) 24 (19 – 42) 0.425
Diagnosis N (%)
 Breast cancer 14 (34)   8 (44) 4 (21) 12 (32)  
 Colorectal cancer 14 (34)   3 (17) 10 (53) 13 (35)  
 Gynecological cancer other than breast 4 (10)   2 (11) 1 (5) 3 (8)  
 Upper gastrointestinal cancer 2 (5)   1 (6) 1 (5) 2 (5)  
 Non-small cell lung cancer 1 (2)   0 (0) 1 (5) 1 (3)  
 Non-Hodgkin’s lymphoma 5 (12)   4 (22) 1 (5) 5 (14)  
 Multiple myeloma 1 (2)   0 (0) 1 (5) 1 (3)  
Therapies N (%)
 Surgery 38 (93)   16 (89) 18 (95) 34 (92)  
 Radiation 15 (37)   8 (44) 5 (26) 13 (35)  
 Hematopoietic cell transplantation 2 (5)   1 (6) 1 (5) 2 (5)  
 Chemotherapy 41 (100)   18 (100) 19 (100) 37 (100)  
   N cycles, median (range) 6 (1 – 18) 0.681 6 (2 – 6) 6 (2 – 16) 6 (2 – 16) 0.775
   N neurotoxic agents, median (range) 2 (1 – 4) 0.115 2 (1 – 4) 1 (1 – 4) 2 (1 – 4) 0.061
   Therapy-free weeks, median (range) 11 (1 – 167) 0.754 10 (1 – 167) 18 (3 – 98) 13 (1 – 167) 0.775
CIPN symptoms N (%)
  Reduced vibration sense* 28 (70)   13 (77) 13 (68) 26 (72)  
  Reduced joint position sense# 11 (28)   5 (29) 6 (32) 11 (31)  
  Reduced temperature sensation 23 (58)   12 (71) 10 (53) 20 (56)  
  Reduced pain sensation 4 (10)   2 (12) 2 (11) 4 (11)  
  Loss of reflexes ASR / PSR 28 (68) / 8 (20)   12 (67) / 3 (17) 13 (68) / 3 (16) 25 (68) / 6 (16)  
Compliance %, median (range) 92 (25 – 100) 0.175 92 (71 – 100) 100 (71 – 100) 96 (71 – 100) 0.118
  1. *measured on the first metacarpophalangeal joint, value < 5 (scale 0–8); #measured on second toe, ≥ 3 failures out of 10 trials in random order; measured on arch, ≥ 3 failures out of 10 trials in random order; bold type indicates significance P<0.05
  2. Abbreviations: ASR Achilles tendon reflex, PSR patellar tendon reflex, IG intervention group, CG control group, BMI body mass index, CIPM chemotherapy-induced peripheral neuropathy