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Table 2 Univariate and multivariate Cox regression analyses for OS and DFS in LUAD cohorts

From: The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma

Variables OS DFS
HR (95% CI) P-value HR (95% CI) P-value
  Univariate analysis
Age (> 65 vs. ≤65) 1.390 (0.985–1.963) 0.061 1.242 (0.852–1.811) 0.260
Sex (female vs. male) 1.019 (0.723–1.437) 0.914 1.119 (0.770–1.627) 0.555
pT (pT3–4 vs. T1–2 + Tx) 2.391 (1.487–3.843) < 0.001 2.629 (1.536–4.501) < 0.001
pN (pN+ vs. N0 + Nx) 2.698 (1.908–3.814) < 0.001 2.236 (1.524–3.280) < 0.001
pM (pM1 vs. M0 + Mx) 2.049 (1.128–3.723) 0.018 2.005 (0.877–4.584) 0.099
PKM2 high & PD-L1 high vs. PKM2 low & PD-L1 low 1.581 (1.359–1.840) < 0.001 1.481 (1.162–1.889) 0.002
  Multivariate analysis
Age (> 65 vs. ≤65) 1.639 (1.142–2.353) 0.007   
pT (pT3–4 vs. T1–2 + Tx) 1.740 (1.057–2.862) 0.029 2.178 (1.252–3.788) 0.006
pN (pN+ vs. N0 + Nx) 2.615 (1.823–3.753) < 0.001 2.153 (1.461–3.174) < 0.001
pM (pM1 vs. M0 + Mx) 1.188 (0.633–2.230) 0.592 1.658 (0.722–3.810) 0.233
PKM2 high & PD-L1 high vs. PKM2 low & PD-L1 low 1.462 (1.246–1.715) < 0.001 1.436 (1.119–1.843) 0.004
  1. Abbreviations: HR hazard ratio, OS overall survival, DFS disease-free survival, CI confidence interval, LUAD lung adenocarcinoma