The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma

BMC Cancer

Table 2 Univariate and multivariate Cox regression analyses for OS and DFS in LUAD cohorts

Variables	OS		DFS
Variables	HR (95% CI)	P-value	HR (95% CI)	P-value
	Univariate analysis
Age (> 65 vs. ≤65)	1.390 (0.985–1.963)	0.061	1.242 (0.852–1.811)	0.260
Sex (female vs. male)	1.019 (0.723–1.437)	0.914	1.119 (0.770–1.627)	0.555
pT (pT3–4 vs. T1–2 + Tx)	2.391 (1.487–3.843)	< 0.001	2.629 (1.536–4.501)	< 0.001
pN (pN+ vs. N0 + Nx)	2.698 (1.908–3.814)	< 0.001	2.236 (1.524–3.280)	< 0.001
pM (pM1 vs. M0 + Mx)	2.049 (1.128–3.723)	0.018	2.005 (0.877–4.584)	0.099
PKM2 high & PD-L1 high vs. PKM2 low & PD-L1 low	1.581 (1.359–1.840)	< 0.001	1.481 (1.162–1.889)	0.002
	Multivariate analysis
Age (> 65 vs. ≤65)	1.639 (1.142–2.353)	0.007
pT (pT3–4 vs. T1–2 + Tx)	1.740 (1.057–2.862)	0.029	2.178 (1.252–3.788)	0.006
pN (pN+ vs. N0 + Nx)	2.615 (1.823–3.753)	< 0.001	2.153 (1.461–3.174)	< 0.001
pM (pM1 vs. M0 + Mx)	1.188 (0.633–2.230)	0.592	1.658 (0.722–3.810)	0.233
PKM2 high & PD-L1 high vs. PKM2 low & PD-L1 low	1.462 (1.246–1.715)	< 0.001	1.436 (1.119–1.843)	0.004

Abbreviations: HR hazard ratio, OS overall survival, DFS disease-free survival, CI confidence interval, LUAD lung adenocarcinoma

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