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Fig. 8 | BMC Cancer

Fig. 8

From: Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

Fig. 8

Schematic outline of possible signaling pathways responsible for different radiation responses of SNB19 cells pre-treated either by MK-2206 (a) or PI-103 (b). Despite strong depletion of p-Akt in MK-2206-treated cells, there was a moderate increase of its downstream p-mTOR (a). In contrast, p-mTOR was decreased in PI-103-treated cells (b) and consequently, its downstream effectors p-4E-BP1 and p-S6 were decreased as well (b). In sharp contrast, in MK-2206-treated cells the levels of p-4E-BP1 and p-S6 remain almost the same as in non-treated cells (A). In addition, inhibiting Akt by MK-2206 moderately stimulates the activity of MEK1/2 and Erk1/2 (A) whereas the effect was not seen after treatment with PI-103 (b). The proposed pathways are derived from the findings shown in Figs. 1, 2, 3, 4, 5, 6, 7 and Additional file 4: Figsure S1-S9, and also from previously published data [37]. Non-detected proteins are marked with dashed lines. Increased and decreased protein expression levels compared to corresponding control cells, are denoted by the symbols ↑ and ↓, respectively, as detected by Western blot analysis. (For details, see the Discussion section)

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