Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases – the multicenter randomized controlled PUMP trial

Table 1 Dose adjustment schedule

	Reference Value (RV)^a Upper limit of normal	% floxuridine dose
Aspartate aminotransferase	2–3 ^a RV	80%
	3–4 ^a RV	50%
	> 4 ^a RV	Hold
Alkaline phosphatase	1.2–1.5 ^a RV	50%
Alkaline phosphatase	> 1.5 ^a RV	Hold
Total bilirubin	1.2–1.5 ^a RV	50%
Total bilirubin	> 1.5 ^a RV	Hold

^aReference value is defined as the patient’s value on the first day of the most recent floxuridine dose

ISSN: 1471-2407