Late presentation of hepatitis B among patients with newly diagnosed hepatocellular carcinoma: a national cohort study

Table 3 Hazard ratios (95% confidence intervals) for all-cause mortality in patients with newly diagnosed hepatocellular carcinoma by hepatitis B presentation group

	Person-years	No. of cases	Incidence rate (per 100 person-years)	Crude HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)
Late presentation	954.1	274	28.7	2.08 (1.69, 2.56)	1.99 (1.61, 2.46)	1.94 (1.57. 2.41)	1.76 (1.42. 2.18)
Irregular visits	1346.7	283	21.0	1.52 (1.24, 1.86)	1.49 (1.21, 1.82)	1.44 (1.17, 1.76)	1.31 (1.06, 1.61)
Regular visits	933.3	128	13.7	Reference	Reference	Reference	Reference
p value				<.001	<.001	<.001	<.001

HR hazard ratio, CI confidence interval.
*HRs were obtained from Cox models with hospital as a stratification factor.
Model 1: Adjusted for sex, age ((≥ 40 – < 50, ≥ 50 – < 60, and ≥ 60 years), and year of HCC diagnosis.
Model 2: Further adjusted for income percentile (≤ 30th, > 30th – ≤ 70th, and > 70th), and residential area (metropolitan and rural).
Model 3: Further adjusted for initial treatment (liver transplantation, resection, radiofrequency ablation, transarterial chemoembolization, other and no treatment)

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