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Table 3 Survival of breast cancer patients according to mean tumor ascorbate or HIF-1 pathway score

From: Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

  Tumor ascorbatea HIF-1 pathway scorea
<mean ≥ mean <mean ≥ mean
Disease-free survival Mean days 2772 3613 3865 2412
95% CI (2142, 3402) (3022, 4204) (3286, 4443) (1787, 3037)
No. events 10 4 3 11
p value 0.173 0.01
Disease-specific survival Mean days 2977 3613 4216 2439
95% CI (2350, 3603) (3022, 4204) (3834, 4598) (1824, 3054)
No. events 8 4 1 11
p value 0.322 0.001
  1. aTumor ascorbate mean: 0.2 nmol/μg DNA, n = 31 below the mean, n = 19 above the mean; Tumor HIF-1 pathway score median: 41.8 (HIF-1 pathway score calculated from relative protein levels of HIF-1α, CA-IX, BNIP-3 and VEGF); n = 28 below and n = 21 above the mean. Significance is indicated when p < 0.05