Skip to main content

Table 3 Survival of breast cancer patients according to mean tumor ascorbate or HIF-1 pathway score

From: Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

 

Tumor ascorbatea

HIF-1 pathway scorea

<mean

≥ mean

<mean

≥ mean

Disease-free survival

Mean days

2772

3613

3865

2412

95% CI

(2142, 3402)

(3022, 4204)

(3286, 4443)

(1787, 3037)

No. events

10

4

3

11

p value

0.173

0.01

Disease-specific survival

Mean days

2977

3613

4216

2439

95% CI

(2350, 3603)

(3022, 4204)

(3834, 4598)

(1824, 3054)

No. events

8

4

1

11

p value

0.322

0.001

  1. aTumor ascorbate mean: 0.2 nmol/μg DNA, n = 31 below the mean, n = 19 above the mean; Tumor HIF-1 pathway score median: 41.8 (HIF-1 pathway score calculated from relative protein levels of HIF-1α, CA-IX, BNIP-3 and VEGF); n = 28 below and n = 21 above the mean. Significance is indicated when p < 0.05
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us