|
Parameter
|
Ascorbate in tumor tissuea
|
|---|
|
<mean
|
>mean
|
p valuee
|
|---|
|
Ethnicity
|
Maori/Pacific
|
7
|
1
|
0.099
|
|
non-Maori/non-Pacific
|
23
|
18
| |
|
undeclared
|
1
|
0
| |
|
Age
|
< 55 year
|
16
|
9
|
0.500
|
|
> 55 years
|
15
|
10
| |
|
Grade
|
1
|
2
|
8
|
0.007
|
|
2
|
15
|
4
| |
|
3
|
14
|
7
| |
|
Tumor Stage
|
1
|
11
|
5
|
0.769
|
|
2
|
19
|
13
| |
|
3
|
1
|
1
| |
|
Nottinghamb
|
≤ 3.4
|
4
|
5
|
0.370
|
|
3.41–5.4
|
14
|
9
| |
|
> 5.4
|
13
|
5
| |
|
Node
|
negative
|
11
|
5
|
0.500
|
|
positive
|
20
|
14
| |
|
Vascular invasion
|
no
|
13
|
10
|
0.357
|
|
yes
|
18
|
8
| |
|
unknown
| |
1
| |
|
Tumor sizec
|
≤ 2 cm
|
12
|
5
|
0.369
|
|
> 2 cm
|
19
|
14
| |
|
DCIS Necrosis
|
no
|
8
|
9
|
0.055
|
|
yes
|
19
|
6
| |
|
unknown
|
4
|
4
| |
|
Hormone Receptor statusd
|
HR+
|
24
|
17
|
0.452
|
|
HR-
|
7
|
2
| |
- aNumber of patients below (n = 31) or above (n = 19) the mean ascorbate level of 0.2 nmol/μg DNA in tumor tissue
- bNottingham prognostic index: calculated from tumor size, number of involved lymph nodes and tumor grade [73], with good, moderate and poor prognosis [74].
- cTumor size, invasive component only, excluding DCIS
- dHormone receptor HR+, ER+(PR+/−, Her2+/−) and includes both Luminal A and B; HR−, ER-PR-(Her2+/−) and includes Her2-enriched and basal-like tumours
- eChi-square or Fisher’s exact test, as appropriate. Significance is indicated when p < 0.05
