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Table 1 Relationship of tumor HIF-1α protein levels and HIF-1 pathway score with clinicopathological parameters

From: Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

Parameter n HIF-1α proteina p value HIF-1 pathway scorea,b p value
Grade 1 7 0.39 ± 0.30 0.14 25.2 ± 9.0 0.004
2 20 0.58 ± 0.37 38.2 ± 15.3
3 22 0.70 ± 0.37 50.5 ± 14.5
Tumor stage 1 16 0.59 ± 0.45 0.70 37.9 ± 16.7 0.042
2 31 0.60 ± 0.33 42.2 ± 15.6
3 2 0.83 ± 0.31 68.7 ± 1.8
Node 0 17 0.53 ± 0.33 0.29 38.9 ± 14.7 0.37
1 32 0.65 ± 0.39 43.4 ± 17.5
Vascular invasion 0 22 0.55 ± 0.43 0.28 36.5 ± 16.2 0.023
1 26 0.67 ± 0.32 47.2 ± 15.3
na 1     
DCIS Necrosis 0 17 0.49 ± 0.31 0.14 31.5 ± 11.1 0.001
1 27 0.65 ± 0.35 47.0 ± 15.8
na 5     
Tumor sizec Pearson correlation 49 R = 0.101 0.49 R = 0.348 0.014
Hormone Receptor Statusd HR+ 39 0.55 ± 0.34 0.02 38.1 ± 15.3 0.001
  HR− 10 0.85 ± 0.40 56.6 ± 13.0
  1. aMean ± SD from n = 49 patients, p values from ANOVA. Significance is indicated when p <0.05
  2. bHIF-1 pathway score calculated from relative protein levels of HIF-1α, CA-IX, BNIP-3 and VEGF
  3. na, not available
  4. cTumor size, invasive component only, excluding DCIS
  5. dHormone receptor HR+, ER+(PR+/−, Her2+/−) and includes both Luminal A and B; HR−, ER-PR-(Her2+/−) and includes Her2-enriched and basal-like tumours
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