|
Parameter
|
n
|
HIF-1α proteina
|
p value
|
HIF-1 pathway scorea,b
|
p value
|
|---|
|
Grade
|
1
|
7
|
0.39 ± 0.30
|
0.14
|
25.2 ± 9.0
|
0.004
|
|
2
|
20
|
0.58 ± 0.37
|
38.2 ± 15.3
|
|
3
|
22
|
0.70 ± 0.37
|
50.5 ± 14.5
|
|
Tumor stage
|
1
|
16
|
0.59 ± 0.45
|
0.70
|
37.9 ± 16.7
|
0.042
|
|
2
|
31
|
0.60 ± 0.33
|
42.2 ± 15.6
|
|
3
|
2
|
0.83 ± 0.31
|
68.7 ± 1.8
|
|
Node
|
0
|
17
|
0.53 ± 0.33
|
0.29
|
38.9 ± 14.7
|
0.37
|
|
1
|
32
|
0.65 ± 0.39
|
43.4 ± 17.5
|
|
Vascular invasion
|
0
|
22
|
0.55 ± 0.43
|
0.28
|
36.5 ± 16.2
|
0.023
|
|
1
|
26
|
0.67 ± 0.32
|
47.2 ± 15.3
|
|
na
|
1
| | | | |
|
DCIS Necrosis
|
0
|
17
|
0.49 ± 0.31
|
0.14
|
31.5 ± 11.1
|
0.001
|
|
1
|
27
|
0.65 ± 0.35
|
47.0 ± 15.8
|
|
na
|
5
| | | | |
|
Tumor sizec
|
Pearson correlation
|
49
|
R = 0.101
|
0.49
|
R = 0.348
|
0.014
|
|
Hormone Receptor Statusd
|
HR+
|
39
|
0.55 ± 0.34
|
0.02
|
38.1 ± 15.3
|
0.001
|
| |
HR−
|
10
|
0.85 ± 0.40
|
56.6 ± 13.0
|
- aMean ± SD from n = 49 patients, p values from ANOVA. Significance is indicated when p <0.05
- bHIF-1 pathway score calculated from relative protein levels of HIF-1α, CA-IX, BNIP-3 and VEGF
- na, not available
- cTumor size, invasive component only, excluding DCIS
- dHormone receptor HR+, ER+(PR+/−, Her2+/−) and includes both Luminal A and B; HR−, ER-PR-(Her2+/−) and includes Her2-enriched and basal-like tumours
