At inclusion | Day 1 | Between day 30–60 | At 6 months | Monthly for first 12 months | Every 3 months thereafter | |
---|---|---|---|---|---|---|
NaF- or PSMA- PET CT (with CT of chest/abdomen/pelvis) | x | |||||
PSA, total testosterone | x | x | x | |||
Radical prostatectomy | x | |||||
SBRT to all sites of metastases | x | |||||
Prostate bed/nodes RT a | ||||||
Lupron depot (6 month)b | x | |||||
Start apalutamide, abiraterone acetate, prednisone b | x | |||||
Stop apalutamide, abiraterone acetate, taper prednisone | x | |||||
Quality-of-life and toxicity assessments | x | x | x |