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Table 1 Genes incorporated in the CAGP

From: Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

Number of genes in common [number of gene lists containing these genes] Genes in CAGP Seven different gene lists with the number of contributing genes (n = total number of genes in the list)
Easton et al. (n = 119) Rahman et al. (n = 114) BROCA v6 (n = 61) GeneRead v2 (Qiagen) (n = 143) Kanchi et al. (n = 47) Wood et al. (n = 178) FaCD (n = 319)
8 [7] ATM, BRCA1, BRCA2, BRIP1, CHEK2, MLH1, PALB2, RAD51C 8 8 8 8 8 8 8
17 [6] BLM, ERCC4, ERCC5, FANCA, FANCC, FANCG, MSH2, MSH6, MUTYH, NBN, PMS2, POLD1, POLE, RAD51D, SLX4, TP53, XPC 17 16 10 17 8 17 17
36 [5] APC, ATR, BAP1, BMPR1A, CDH1, CDK4, CDKN2A, DDB2, ERCC2, ERCC3, FANCB, FANCD2, FANCE, FANCF, FANCI, FANCL, FANCM, FH, FLCN, MEN1, MRE11A, NF1, PRKAR1A, PTCH1, PTEN, RB1, RECQL4, RET, SDHB, SDHC, SDHD, SMAD4, STK11, VHL, WRN, XPA 36 27 23 36 8 15 35
36 [4] ALK, AXIN2, BARD1, BUB1B, CDC73, CHEK1, CYLD, DICER1, DIS3L2, EPCAM, EXT1, EXT2, GATA2, GPC3, HRAS, KIT, MAX, MET, NF2, PALLD, PIK3CA, POLH, PRSS1, RAD51B, RHBDF2, RUNX1, SBDS, SDHAF2, SMARCA4, SMARCB1, SUFU, TMEM127, TSC1, TSC2, WT1, XRCC2 33 29 10 34 0 4 34
24 [3] AKT1, CDKN1B, CEBPA, CTNNA1, DKC1, EGFR, EXO1, FAH, GALNT12, GEN1, GREM1, HFE, HOXB13, MLH3, PDGFRA, PHOX2B, RAD50, RAD51, SDHA, TERT, TGFBR1, UROD, WAS, XRCC3 12 13 6 15 2 6 18
56 [2] AIP, ANTXR1, ANTXR2, ATRIP, CBL, CD96, CDKN1C, CEP57, COL7A1, CTNNB1, EHBP1, ELANE, EME1, EPHB2, ERCC1, ERCC6, ESCO2, FAM175A, FAS, GBA, GJB2, GLI3, GLMN, HMBS, HNF1A, KDR, LIG4, LYST, MC1R, MITF, MTAP, NSD1, PDE11A, PMS1, POLI, POLK, PRF1, PTCH2, PTPN11, REV3L, RINT1, RMRP, RNASEL, RPA1, RPA2, RPA4, RSPO1, SERPINA1, SH2D1A, SOS1, SRY, STAT3, TINF2, TP53BP1, TRIM37, UNG 10 16 2 21 9 14 40
315 [1] ABCB11, ABCC11, ACVRL1, ADA, ADH1C, AFP, AICDA, AIRE, AKR1A1, ALKBH2, ALKBH3, AMH, AP3B1, APEX1, APEX2, APITD1, APLF, APTX, AR, ARL6, ASCC1, ATP2C1, ATP7B, ATP8B1, AXIN1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BLOC1S3, BRAF, BTK, CCM2, CCNH, CD40, CD40LG, CDK7, CDKN1A, CDKN2B, CDKN2C, CDKN2D, CETN2, CFTR, CHAF1A, CLK2, COL17A1, COL4A5, COL4A6, CREBBP, CSH1, CXCR4, CYP11B1, CYP11B2, CYP1A1, CYP21A2, CYP2E1, CYP7A1, DAPK1, DCLRE1A, DCLRE1B, DCLRE1C, DDB1, DHCR7, DMC1, DNAAF1, DNAAF2, DNAH11, DNAH5, DNAI1, DNAI2, DOCK8, DTNBP1, DUT, ELAC2, EME2, ENDOV, ENG, EP300, EPAS1, ERCC8, EZH2, F12, FAAP20, FAAP24, FAN1, FEN1, FGFR2, FGFR3, FHIT, FLG, FLT4, FMR1, FOXC2, FOXI1, FSHR, G6PC, GALT, GBE1, GNAS, GRB10, GSTM1, GSTT1, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, H19, H2AFX, HAX1, HBB, HELQ, HES1, HLA-A, HLA-B, HLA-DQB1, HLA-DRA, HLA-DRB1, HLTF, HMGA2, HNF1B, HPS1, HPS3, HPS4, HPS5, HPS6, HUS1, IDH1, IDH2, IL1RN, IL2RG, ITK, JAG1, JAK2, KCNQ1OT1, KIF1B, KITLG, KLHDC8B, KRAS, KRIT1, KRT17, LHCGR, LIG1, LIG3, LMNA, LMX1B, LZTR1, MAD2L2, MAP2K1, MAP2K2, MBD4, MDC1, MGMT, MKKS, MMS19, MNAT1, MNX1, MPG, MPLKIP, MSH3, MSH4, MSH5, MSMB, MSR1, MUS81, MYH8, MYH9, NABP2, NAT2, NDN, NDUFA13, NEIL1, NEIL2, NEIL3, NHEJ1, NME8, NOTCH2, NRAS, NTHL1, NTRK1, NUDT1, OCA2, OGG1, PARP1, PARP2, PARP3, PAX5, PAX6, PCA3, PCNA, PDCD10, PDK1, PDK2, PDPK1, PER1, PMS2CL, PMS2P3, PNKP, POLB, POLG, POLL, POLM, POLN, POLQ, POT1, POU6F2, PPM1D, PPOX, PRKDC, PRPF19, PTH1R, PTPRJ, RAD1, RAD17, RAD18, RAD23A, RAD23B, RAD52, RAD54B, RAD54L, RAD9A, RAF1, RAG1, RAG2, RBBP8, RDM1, RECQL, RECQL5, REV1, RGS17, RIF1, RMI1, RMI2, RNF139, RNF168, RNF4, RNF8, RPA3, RPS19, RPS20, RRM2B, RSPH4A, RSPH9, RTEL1, SART3, SERPING1, SETBP1, SETMAR, SFTPA2, SH3BP2, SHFM1, SHOX, SHPRH, SIL1, SLC25A13, SLC26A4, SLC37A4, SLX1A, SLX1B, SMARCAL1, SMARCE1, SMC1A, SMC3, SMUG1, SNRPN, SPINK1, SPO11, SPRED1, SPRTN, SPRY4, SQSTM1, STS, STX11, T, TDG, TDP1, TDP2, TELO2, TERC, TGFBR2, TMC6, TMC8, TNF, TNFRSF11A, TNFRSF13B, TOP3A, TOP3B, TOPBP1, TP63, TREX1, TREX2, TRIM32, TRPS1, TTC8, TWIST1, TYR, TYRP1, UBE2A, UBE2B, UBE2N, UBE2V2, UNC13D, USP1, UVSSA, WDR48, XAB2, XIAP, XRCC1, XRCC4, XRCC5, XRCC6 3 5 2 12 12 114 167
  1. This panel of genes is the aggregation of seven different lists of genes found in the literature. The name and number of genes contributed by each gene list is indicated
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