Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

Table 2 The results of HPV E6/E7 mRNA expression levels in different levels of cervical lesion

Group	expression levels (copies / ml)^a	Average rank	Z value	p value
cervical inflammation	0(0–1586.03)
CIN1	2643.67(0–17,497.47)
CIN2	4354.17(1669.85–34,429.90)
CIN3+	6022.75(866.28–16,847.81)
CIN1-	560.98(0–4253.46)	139.70	−4.728	< 0.001
CIN2+	4815.42(1011.54–19,392.66)	199.71

^aMedian of mRNA load, with 25th–75th percentile in parentheses; CIN: cervical intraepithelial neoplasia; CIN1-: The diagnoses of cervical inflammation and CIN1 are referred as CIN1 -; CIN2+: the diagnoses of CIN2, CIN3 and carcinoma are referred as CIN2 +. CIN3+: the diagnoses of CIN3 and carcinoma are referred as CIN3 +

ISSN: 1471-2407