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Table 1 Main characteristics of the included studies

From: Effectiveness of 18F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies

Study, year Country No. of Subjects Gender (M/F) Median/Mean age (years) Age range (years) Design Inclusion interval QUADAS scores
Kole,1998 [13] Netherlands 5 3/2 20/20.2 17–24 Retrospective NR 13
Schulte,1999 [14] Germany 27 17/10 17/NR 5–36 Prospective Jan.1993-NR 11
Franzius,2000 [15] Germany 32 NR NR NR Retrospective Aug.1995-Jun.1999 11
Schulte,2000 [16] Germany 44 NR NR NR Retrospective Jan.1993-NR 12
Franzius,2001 [17] Germany 32 NR NR NR Retrospective Aug.1995-Jun.1999 11
Franzius,2002 [18] Germany 6 NR NR NR Retrospective NR 11
Yanagawa,2003 [19] Japan 5 4/1 14/14.4 11–20 Prospective Jun.1999-Mar.2000 13
Kneisl,2006 [20] USA 38 NR NR NR Retrospective Dec.1994-Nov.2004 13
Iagaru,2006 [21] USA 6 NR NR NR Retrospective Jan.2003-Dec.2005 12
Volker,2007 [22] Germany 11 NR NR 1–18 Prospective Dec.2003-Oct.2006 9
Shin,2008 [23] South Korea 7 NR NR 6–79 Retrospective May.2004-Jun.2007 12
Charest,2009 [24] Canada 24 NR NR NR Retrospective May.2004-Apr.2008 12
Hawkins,2009 [25] USA 40 NR 15.1/NR 7.1–31 Prospective Jul.1995-Aug.2004 11
Benz,2010 [26] USA 6 2/4 27/30.8 18–58 Prospective Feb.2005-Nov.2007 13
Lindholm,2011 [27] Finland 6 4/2 16.5/16.5 15–18 Prospective NR 13
Bandopadhyaya,2012 [30] India 22 14/8 21.55/NR 8–66 Prospective NR 13
Cistaro,2012 [28] Italy 11 NR NR/14 NR NR NR 13
Ozkan,2012 [29] Turkey 7 6/1 25/26.1 18–50 Retrospective 2007–2009 11
Bai,2013 [33] China 14 9/5 NR/14.9 8–22 Retrospective Jan.2009-Nov.2011 13
Byun,2013 [31] South Korea 206 127/79 15/NR 4–71 Retrospective Jan.2006-Nov.2011 11
Kong,2013 [32] South Korea 26 16/10 NR/21 9–55 Prospective May.2010-Aug.2011 12
Chang,2015 [35] South Korea 109 74/35 NR/17 NR Retrospective Feb.2002-Sep.2012 11
Quartuccio,2015 [34] Italy 20 10/10 15.5/NR NR Retrospective Jan.2006-Sep.2010 11
Hurley, 2016 [36] USA 39 19/20 Median 12 5–19 Retrospective 2003–2012 13
Angelini, 2017 [38] Italy 37 20/17 Mean 20 7–52 Retrospective 2008–2014 13
Sharp, 2017 [37] USA 8 5/3 Median 13 8–16 Retrospective Oct.2004-Feb. 2013 13
  1. M male, F female, NR not reported