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Table 1 Main characteristics of the included studies

From: Effectiveness of 18F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies

Study, year

Country

No. of Subjects

Gender (M/F)

Median/Mean age (years)

Age range (years)

Design

Inclusion interval

QUADAS scores

Kole,1998 [13]

Netherlands

5

3/2

20/20.2

17–24

Retrospective

NR

13

Schulte,1999 [14]

Germany

27

17/10

17/NR

5–36

Prospective

Jan.1993-NR

11

Franzius,2000 [15]

Germany

32

NR

NR

NR

Retrospective

Aug.1995-Jun.1999

11

Schulte,2000 [16]

Germany

44

NR

NR

NR

Retrospective

Jan.1993-NR

12

Franzius,2001 [17]

Germany

32

NR

NR

NR

Retrospective

Aug.1995-Jun.1999

11

Franzius,2002 [18]

Germany

6

NR

NR

NR

Retrospective

NR

11

Yanagawa,2003 [19]

Japan

5

4/1

14/14.4

11–20

Prospective

Jun.1999-Mar.2000

13

Kneisl,2006 [20]

USA

38

NR

NR

NR

Retrospective

Dec.1994-Nov.2004

13

Iagaru,2006 [21]

USA

6

NR

NR

NR

Retrospective

Jan.2003-Dec.2005

12

Volker,2007 [22]

Germany

11

NR

NR

1–18

Prospective

Dec.2003-Oct.2006

9

Shin,2008 [23]

South Korea

7

NR

NR

6–79

Retrospective

May.2004-Jun.2007

12

Charest,2009 [24]

Canada

24

NR

NR

NR

Retrospective

May.2004-Apr.2008

12

Hawkins,2009 [25]

USA

40

NR

15.1/NR

7.1–31

Prospective

Jul.1995-Aug.2004

11

Benz,2010 [26]

USA

6

2/4

27/30.8

18–58

Prospective

Feb.2005-Nov.2007

13

Lindholm,2011 [27]

Finland

6

4/2

16.5/16.5

15–18

Prospective

NR

13

Bandopadhyaya,2012 [30]

India

22

14/8

21.55/NR

8–66

Prospective

NR

13

Cistaro,2012 [28]

Italy

11

NR

NR/14

NR

NR

NR

13

Ozkan,2012 [29]

Turkey

7

6/1

25/26.1

18–50

Retrospective

2007–2009

11

Bai,2013 [33]

China

14

9/5

NR/14.9

8–22

Retrospective

Jan.2009-Nov.2011

13

Byun,2013 [31]

South Korea

206

127/79

15/NR

4–71

Retrospective

Jan.2006-Nov.2011

11

Kong,2013 [32]

South Korea

26

16/10

NR/21

9–55

Prospective

May.2010-Aug.2011

12

Chang,2015 [35]

South Korea

109

74/35

NR/17

NR

Retrospective

Feb.2002-Sep.2012

11

Quartuccio,2015 [34]

Italy

20

10/10

15.5/NR

NR

Retrospective

Jan.2006-Sep.2010

11

Hurley, 2016 [36]

USA

39

19/20

Median 12

5–19

Retrospective

2003–2012

13

Angelini, 2017 [38]

Italy

37

20/17

Mean 20

7–52

Retrospective

2008–2014

13

Sharp, 2017 [37]

USA

8

5/3

Median 13

8–16

Retrospective

Oct.2004-Feb. 2013

13

  1. M male, F female, NR not reported