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Fig. 3 | BMC Cancer

Fig. 3

From: Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib

Fig. 3

CNA profiles for hepatocellular carcinoma cfDNA. (a) Circos plot of the distribution of CNA in the chromosomes of 151 patients. The chromosome map is located on the external periphery with the centromere in blue. The relative chromosomal deviations of individual cfDNA samples from the means of reference samples, expressed as Z-scores (red represents gain; blue represents loss) are illustrated as inner wheels. (bc) Representative I-score profiles of three patients. Each point represents the normalized read count ratio of a 1 Mb-sized bin. Separate chromosomes from 1 to 22 are shown, and a Z-score of zero corresponds to a copy number of 2. Abbreviations: CNA, copy number alteration; cfDNA, cell-free DNA

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