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Table 2 Characteristics of Included Studies

From: First-line cetuximab versus bevacizumab for RAS and BRAF wild-type metastatic colorectal cancer: a systematic review and meta-analysis

Study

TN

Age(C/B,yeas) (Median, range)

Number (C/B)

Male(C/B)

SM(C/B)

Primary Tumor Site(C/B)

Metastatic cancer in one Site(C/B)

Venook AP 2017

1137

59.2 (20.8–89.5)/59.0 (21.8–85.0)

578/559

349/348

447/445

Ri:138,L:355,T:31,T:1,Un:53/Ri:142,L:34,T:31,T:0,Un:52

187/165(liver only)

FIRE-3

592

<65y:158/160;>65y:139/135

297/295

214/196

Un

Co:168,Re:115/Co:177,Re:106

119/123

Houts AC 2017

400

61.8 ± 12.65/61.7 ± 11.77

146/254

93/140

73/167

Ri:43,L:92,Un:11/Ri:79,L:162,Un:13

Un

2016 Bai L

289

55 (21–83)/50 (24–79)

101/188

68/120

Un

Co:65,Re:36/ Co:116,Re:70

64/106

2014 Yang YH

158

<60Y:38/43; >60Y:25/52

63/95

34/63

Un

Co:49,Re:14/ Co:72,Re:23

Un

  1. TN total number, SM Synchronous Metastases, C cetuximab, B bevacizumab, Ri Right, L left, Re rectum, T Transverse, M Multiple, Un unknown, Co colon