Table 2 Significant functional clusters among post-FOLFOX unique mutations
Gene Ontology term | Gene symbol | Adjusted P value | |||
|---|---|---|---|---|---|
Case 1 | Case 2 | Case 3 | Case 4 | ||
GO:0007155~cell adhesion | – | CDH9 TRPM7 COL22A1 NLGN4X PCDH17 | PCDHA9 PDZD2 | – | 0.033 |
GO:0030695~GTPase regulator activity | – | DOCK1 TBC1D9 RICTOR IQSEC1 | – | TBC1D12 | 0.037 |
GO:0006816~calcium ion transport | CACNA1E | TRPM7 TRPV5 SLC24A6 | – | JPH3 | 0.0014 |
GO:0005509~calcium ion binding | CACNA1E | CDH9 TRPM7 TBC1D9 TRPV5 SLC24A6 PCDH17 | PDCHA9 PLCB3 | DOC2A RUNX1 | 0.00044 |