Fig. 2

Comparison of the mutation spectrum among unique mutations: The relative frequencies of 96 trinucleotides are shown for unique mutations in the primary, pre-FOLFOX metastatic, and post-FOLFOX metastatic tumor samples. The presented number of mutations is the sum of the data recorded for the four patients. For specific mutation types, a Wilcoxon signed-rank test was used, and significant enrichment in the platinum exposure signature, C > A in a CpC context (equivalently, G > T in a GpG context), was not observed