Skip to main content

Table 1 Baseline characteristics of HCC patients

From: First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

Characteristic   Icaritin  
600 mg bid 800mg bid Total
(N = 14) (N = 6) (N = 20)
Median age, years (range) 61 (31–74) 43 (33–73) 58 (31–74)
Male, no.(%) 12 (85.7) 5 (83.3) 17 (85.0)
ECOG performance status, no.(%)
 0 2 (14.3) 0 (0.0) 2 (10.0)
 1 11 (78.6) 6 (100.0) 17 (85.0)
 2 1 (7.1) 0 (0.0) 1 (5.0)
Macroscopic vascular invasion, no.(%)
 Yes 5 (35.7) 2 (33.3) 7 (35.0)
 No 9 (64.3) 4 (66.7) 13 (65.0)
Portal vein tumor thrombus, no.(%)
 Yes 3 (21.4) 2 (33.3) 5 (25.0)
 No 11 (78.6) 4 (66.7) 15 (75.0)
Bulky tumor*, no.(%)
 Yes 1 (7.1) 1 (16.7) 2 (10.0)
 No 13 (92.9) 5 (83.3) 18(90.0)
Extrahepatic metastasis, no.(%)
 Yes 13 (92.9) 5 (83.3) 18 (90.0)
 No 1 (7.1) 1 (16.7) 2 (10.0)
Extrahepatic metastatic site, no.(%)
 Lymph node 7 (50.0) 4 (66.7) 11 (55.0)
 Lung 7 (50.0) 3 (50.0) 10 (50.0)
BCLC stage, no.(%)
 B 1 (7.1) 0 (0.0) 1 (5.0)
 C 13 (92.9) 6 (100.0) 19 (95.0)
Number of tumor sites, no.(%)
 1 2 (14.3) 1 (16.7) 3 (15.0)
 2 6 (42.9) 1 (16.7) 7 (35.0)
 3 3 (21.4) 2 (33.3) 5 (25.0)
  ≥ 4 3 (21.4) 2 (33.3) 5 (25.0)
Hepatitis virus status, no.(%)
 HBV infection 12(85.7) 6 (100.0) 18 (90.0)
 HCV infection 1 (7.1) 0 (0.0) 1 (5.0)
Liver cirrhosis, no.(%)
 Yes 10 (71.4) 5 (83.3) 15 (75.0)
 No 4 (28.6) 1 (16.7) 5 (25.0)
Child-Pugh classification, no.(%)
 A 13 (92.9) 5 (83.3) 18 (90.0)
 B 1 (7.1) 1 (16.7) 2 (10.0)
 AFP > ULN (laboratory), no.(%) 13 (92.9) 6 (100.0) 19 (95.0)
Previous treatment, no.(%)
 Surgery 3 (21.4) 4 (66.7) 7 (35.0)
 TACE/RFA 11 (78.6) 3 (50.0) 14 (70.0)
 Sorafenib or Chemo 1 (7.1) 3 (50.0) 4 (20.0)
  1. *Bulky tumor: Tumor mass in liver ≥10cm. Abbreviations: ECOG: Eastern Cooperative Oncology Group; BCLC: Barcelona Clinic Liver Cancer; HBV: Hepatitis B Virus; HCV: Hepatitis C Virus; ULN: Upper Limits of Normal; TACE: Transarterial Chemoembolization; RFA: Radiofrequency Ablation