Table 2 Expression and co-expression in different location and cell types of fibroblast and stromal markers analyzed in this study
Markers | Expression of the marker | Subpopulations |
|---|---|---|
CD31 | Blood vessels | Endothelial cells |
αSMA | Cancer stroma Blood vessels | CAFs, Smooth muscle cells Myofibroblasts in healthy colon |
PDGFRβ | Cancer stroma Blood vessels | CAFs, myofibroblasts, pericytes |
FAP | Cancer stroma | CAFs |
CD45 | Immune cells | Immune cells, hematopoietic stem cells |
FSP1 | Fibroblasts | Quiescent fibroblasts, cancer cells |
PDGFRβ αSMA | Around CD31+ endothelial cells | Pericytes, smooth muscle cells? |
Cancer stroma | CAFs | |
FAP αSMA | Cancer stroma | CAFs |
PDGFRβ αSMA FAP | Cancer stroma | CAFs |
CD45 FSP1 | Cancer stroma | Macrophages / monocytes / fibroblast precursors or quiescent fibroblasts (?) |