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Fig. 2 | BMC Cancer

Fig. 2

From: Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Fig. 2

Multiplex analysis of cancer-associated fibroblast markers in a cohort of stage III colon cancer. Representation of enlarged 40x fields of the extracellular matrix-related markers showing the individual markers FAP (a), PDGFRβ (b), αSMA (c) and CD31 (d) together with DAPI (grey), and the composite image using the same colors (e). Representations showing co-expression (orange) of PDGFRβ and αSMA around CD31(f) and co-expression (pink) of FAP and αSMA around tumor cells (g). Representation of enlarged 40x fields of the immune-related fibroblast markers showing the individual markers DAPI (h), αSMA (i), FSP1 (j) and CD45 (k) together with DAPI and the composite image showing co-expression of CD45 and FSP1 (white arrow, l). FSP1 was also expressed in some cancer cells (green arrow, l)

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