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Table 3 Univariable and multivariable analyses of metastatic survival duration in 108 patients

From: Risk factors affecting prognosis in metachronous liver metastases from WHO classification G1 and G2 gastroenteropancreatic neuroendocrine tumors after initial R0 surgical resection

Prognostic factors Univariable analysis Multivariable analysis
  HR (95% CI) P-value HR (95% CI) P-value
Age   0.818   0.361
 <60 1.161 (0.575–2.344)   1.328 (0.722–2.442)  
 ≥60 1   1  
Gender   0.287   0.063
 Male 1.375 (0.545–3.470)   0.511 (0.252–1.036)  
 Female 1   1  
Primary tumor Grade   0.0028   0.293
 G1 0.502 (0.144–0.756)   0.51 (0.147–1.782)  
 G2 1   1  
Hepatic Tumor Number   0.000   0.000
 Single 0.17 (0.123–0.214)   0.07 (0.023–0.214)  
 Multiple 1   1  
Lymph-node meta   0.035   0.374
 Present 1.057 (0.393–2.839)   0.988 (0.371–2.629)  
 Absent 1   1  
Tumor origin   0.273   0.329
 Pancreas 0.490 (0.139–1.732)   1.463 (0.682–3.138)  
 GI tract 1   1  
Treatment modality   0.009   0.045
 Local treatment 0.817 (0.690–0.917)   0.801 (0.684–0.887)  
 Systemic treatment 0.921 (0.702–0.998)   0.922 (0.781–0.998)  
 Combined treatment 1   1  
Elevation of ki67 index   0.022   0.027
 Yes 1.997 (1.018–3.547)   1.396 (1.174–3.483)  
 No 1   1  
Longest hepatic tumor diameter   0.343   0.775
 > 4.5 0.644 (0.2–2.072)   0.875 (0.352–2.175)  
 <=4.5 1   1