Fig. 5
From: Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells
Bortezomib inhibition of the proteasome in PANC-1 cells results in decreased viability and cell death. a Bortezomib dosage in PANC-1 cells and percentage viability after 96 h of treatment. b Representative flow cytometry panels of PANC-1 cells and c quantification of PANC-1 cells and Mia PaCa-2 cells treated with 1 nM bortezomib for 48 h then stained with 7-AAD and Annexin V to assess cell apoptosis. (*P = 0.05, **P = 0.01; ****P = 0.0001)