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Table 7 Cox proportional hazard analysis for clinical variables in relationship to overall survival in INR < 1.1 subgroup (n = 270)

From: Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

  HR 95% CI P
Univariate analysis
 Age, per year 1.003 0.977 – 1.029 0.840
 Gender, Male = 1 0.438 0.205 – 0.936 0.033
 Anti-HCV, positive = 1 1.277 0.540 – 3.021 0.578
 HBsAg, positive = 1 0.501 0.232 – 1.081 0.078
 Liver cirrhosis, yes = 1 1.112 0.522 – 2.366 0.783
 Microvascular invasion, yes = 1 1.775 0.812 – 3.884 0.151
 Macrovascular invasion, yes = 1 1.385 0.327 – 5.870 0.659
 Histology grade, per grade 0.837 0.461 – 1.521 0.560
 Capsule, yes = 1 0.974 0.411 – 2.309 0.953
 Tumor number, per number 0.998 0.653 – 1.525 0.994
 Ascites yes = 1 3.198 0.960 – 10.654 0.058
 Alcoholism yes = 1 1.386 0.606 – 3.171 0.440
 Largest tumor size, per cm 1.077 0.994 – 1.168 0.071
 AFP, per 1000 ng/mL 1.002 0.998 – 1.006 0.346
 Albumin, per g/L 0.441 0.208 – 0.937 0.033
 Bilirubin, per mg/dL 1.725 1.086 – 2.740 0.021
 PT, per sec 0.695 0.374 – 1.293 0.251
 Creatinine, per mg/dL 0.967 0.709 – 1.320 0.834
 AST, per U/L 1.003 0.999 – 1.006 0.193
 ALT, per U/L 1.000 0.995 – 1.005 0.997
Multivariate analysis
 Gender, Male = 1 0.441 0.201 – 0.971 0.042
 Albumin, per g/dL 0.560 0.270 – 1.160 0.119
 Bilirubin, per mg/dL 1.802 1.131 – 2.870 0.013
  1. INR international normalized ratio, AFP alpha-fetoprotein, PT prothrombin time, AST aspartate aminotransferase, ALT alanine aminotransferase, HR hazard ratio, CI confidence interval; Values in bold, P < 0.05