Table 7 Cox proportional hazard analysis for clinical variables in relationship to overall survival in INR < 1.1 subgroup (n = 270)

 Age, per year

1.003

0.977 – 1.029

0.840

 Gender, Male = 1

0.438

0.205 – 0.936

0.033

 Anti-HCV, positive = 1

1.277

0.540 – 3.021

0.578

 HBsAg, positive = 1

0.501

0.232 – 1.081

0.078

 Liver cirrhosis, yes = 1

1.112

0.522 – 2.366

0.783

 Microvascular invasion, yes = 1

1.775

0.812 – 3.884

0.151

 Macrovascular invasion, yes = 1

1.385

0.327 – 5.870

0.659

 Histology grade, per grade

0.837

0.461 – 1.521

0.560

 Capsule, yes = 1

0.974

0.411 – 2.309

0.953

 Tumor number, per number

0.998

0.653 – 1.525

0.994

 Ascites yes = 1

3.198

0.960 – 10.654

0.058

 Alcoholism yes = 1

1.386

0.606 – 3.171

0.440

 Largest tumor size, per cm

1.077

0.994 – 1.168

0.071

 AFP, per 1000 ng/mL

1.002

0.998 – 1.006

0.346

 Albumin, per g/L

0.441

0.208 – 0.937

0.033

 Bilirubin, per mg/dL

1.725

1.086 – 2.740

0.021

 PT, per sec

0.695

0.374 – 1.293

0.251

 Creatinine, per mg/dL

0.967

0.709 – 1.320

0.834

 AST, per U/L

1.003

0.999 – 1.006

0.193

 ALT, per U/L

1.000

0.995 – 1.005

0.997

 Gender, Male = 1

0.441

0.201 – 0.971

0.042

 Albumin, per g/dL

0.560

0.270 – 1.160

0.119

 Bilirubin, per mg/dL

1.802

1.131 – 2.870

0.013