Table 6 Cox proportional hazard analysis for sex difference in relationship to overall survival in various clinical subgroups (Male = 1)

Overall

516

0.881

0.513 – 1.513

0.646

Age, years

<58

262

1.671

0.590 – 4.735

0.334

≥58

254

0.567

0.279 – 1.152

0.117

Anti-HCV

Negative

381

0.892

0.468 – 1.701

0.729

Positive

135

0.813

0.288 – 2.291

0.695

HBsAg

Negative

157

0.556

0.236 – 1.309

0.179

Positive

359

1.244

0.580 – 2.669

0.575

Liver cirrhosis

No

219

1.573

0.602 – 4.111

0.356

Yes

297

0.625

0.318 – 1.228

0.172

Microvascular invasion

No

343

0.830

0.420 – 1.641

0.593

Yes

173

0.751

0.304 – 1.854

0.535

Macrovascular invasion

No

449

0.924

0.502 – 1.699

0.798

Yes

67

0.629

0.189 – 2.102

0.452

Histology grade

<3

233

1.005

0.403 – 2.509

0.991

≥3

283

0.831

0.424 – 1.630

0.590

Capsule

No

141

0.621

0.231 – 1.617

0.322

Yes

375

0.987

0.512 – 1.903

0.970

Tumor number

1

306

0.671

0.344 – 1.306

0.240

>1

210

1.349

0.512 – 3.555

0.545

Ascites

No

477

0.880

0.487 – 1.591

0.672

Yes

39

0.965

0.254 – 3.662

0.958

Alcoholism

No

383

0.768

0.426 – 1.385

0.381

Yes

133

20.814

0.000 - 29575628

0.675

Largest tumor size, cm

≤4

242

0.609

0.252 – 1.470

0.270

>4

274

1.023

0.507 – 2.062

0.950

AFP, ng/mL

≤35

270

1.003

0.374 – 2.689

0.996

>35

246

0.968

0.504 – 1.858

0.923

Albumin, g/L

≤4

279

1.064

0.519 – 2.180

0.866

>4

237

0.658

0.288 – 1.504

0.321

Bilirubin, mg/dL

≤0.8

263

0.674

0.327 – 1.390

0.285

>0.8

253

1.129

0.469 – 2.721

0.786

PT, sec

<12

259

0.455

0.213 – 0.972

0.042

≥12

257

1.61

0.671 – 3.819

0.289

PT, INR

<1.1

270

0.438

0.205 – 0.936

0.033

≥1.1

246

1.677

0.703 – 4.001

0.243

Creatinine, mg/dL

≤1

294

1.122

0.590 – 2.136

0.725

>1

222

0.445

0.152 – 1.301

0.139

AST, U/L

≤39

262

0.836

0.370 – 1.889

0.667

>39

254

0.931

0.452 – 1.920

0.847

ALT, U/L

≤40

255

0.790

0.390 – 1.597

0.511

>40

261

1.092

0.451 – 2.647

0.845