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Table 4 Cox proportional hazard analysis for sex difference in relationship to metastasis-free survival in various clinical subgroups (Male = 1)

From: Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

   No. of patients HR 95% CI P
Overall   516 1.328 0.805 – 2.193 0.267
Age, years <58 262 0.957 0.496 – 1.847 0.896
≥58 254 1.731 0.793 – 3.779 0.169
Anti-HCV Negative 381 1.272 0.701 – 2.307 0.429
Positive 135 1.369 0.523 – 3.583 0.522
HBsAg Negative 157 2.159 0.876 – 5.321 0.094
Positive 359 1.049 0.574 – 1.918 0.877
Liver cirrhosis No 219 1.272 0.615 – 2.632 0.517
Yes 297 1.373 0.688 – 2.742 0.368
Microvascular invasion No 343 1.024 0.541 – 1.937 0.943
Yes 173 1.324 0.562 – 3.119 0.521
Macrovascular invasion No 449 1.331 0.758 – 2.340 0.320
Yes 67 1.147 0.379 – 3.477 0.808
Histology grade <3 233 2.094 0.816 – 5.370 0.124
≥3 283 1.076 0.592 – 1.958 0.809
Capsule No 141 0.868 0.366 – 2.056 0.747
Yes 375 1.550 0.831 – 2.890 0.168
Tumor number 1 306 1.242 0.639 – 2.415 0.523
>1 210 1.362 0.631 – 2.940 0.431
Ascites No 477 1.246 0.753 – 2.061 0.392
Yes 39 31.863 0.002 - 458965 0.479
Alcoholism No 383 1.248 0.736 – 2.116 0.411
Yes 133 20.884 0.000 - 1274875 0.589
Largest tumor size, cm ≤4 242 1.851 0.769 – 4.456 0.169
>4 274 1.060 0.575 – 1.952 0.852
AFP, ng/mL ≤35 270 3.572 1.104 – 11.553 0.034
>35 246 0.956 0.534 – 1.714 0.881
Albumin, g/L ≤4 279 1.378 0.728 – 2.606 0.325
>4 237 1.356 0.601 – 3.061 0.463
Bilirubin, mg/dL ≤0.8 263 1.418 0.746 – 2.694 0.287
>0.8 253 1.154 0.511 – 2.604 0.730
PT, sec <12 259 1.105 0.559 – 2.184 0.774
≥12 257 1.572 0.740 – 3.340 0.239
PT, INR <1.1 270 1.189 0.607 – 2.328 0.614
≥1.1 246 1.496 0.700 – 3.195 0.299
Creatinine, mg/dL ≤1 294 1.325 0.776 – 2.265 0.303
>1 222 22.955 0.098 - 5387 0.261
AST, U/L ≤39 262 1.124 0.538 – 2.351 0.756
>39 254 1.511 0.761 – 3.000 0.238
ALT, U/L ≤40 255 1.695 0.849 – 3.384 0.134
>40 261 1.040 0.503 – 2.153 0.915
  1. AFP alpha-fetoprotein, PT prothrombin time, INR international normalized ratio, AST aspartate aminotransferase, ALT alanine aminotransferase, HR hazard ratio, CI confidence interval; Values in bold, P < 0.05