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Table 3 Cox proportional hazard analysis for clinical variables in relationship to recurrence-free survival in AFP ≤ 35 ng/mL subgroup (n = 270)

From: Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

  HR 95% CI P
Univariate analysis
 Age, per year 1.013 0.999 – 1.027 0.070
 Gender, Male = 1 1.796 1.102 – 2.926 0.019
 Anti-HCV, positive = 1 1.299 0.882 – 1.915 0.186
 HBsAg, positive = 1 0.867 0.597 – 1.259 0.454
 Liver cirrhosis, yes = 1 1.379 0.961 – 1.979 0.081
 Microvascular invasion, yes = 1 2.285 1.582 – 3.302 < 0.001
 Macrovascular invasion, yes = 1 2.003 1.181 – 3.398 0.010
 Histology grade, per grade 1.340 1.035 – 1.735 0.026
 Capsule, yes = 1 1.040 0.709 – 1.526 0.840
 Tumor number, per number 1.207 1.021 – 1.427 0.027
 Ascites yes = 1 2.309 1.169 – 4.561 0.016
 Alcoholism yes = 1 1.170 0.799 – 1.713 0.419
 Largest tumor size, per cm 0.997 0.970 – 1.025 0.838
 AFP, per ng/mL 1.034 1.014 – 1.055 0.001
 Albumin, per g/L 0.642 0.431 – 0.857 0.003
 Bilirubin, per mg/dL 0.919 0.765 – 1.105 0.371
 PT, per sec 1.074 0.966 – 1.195 0.187
 Creatinine, per mg/dL 1.039 0.884 – 1.220 0.645
 AST, per U/L 1.003 1.001 – 1.004 0.001
 ALT, per U/L 1.002 1.000 – 1.003 0.011
Multivariate analysis
 Gender, Male = 1 1.997 1.198 – 3.327 0.008
 Microvascular invasion, yes = 1 2.057 1.381 – 3.062 < 0.001
 Macrovascular invasion, yes = 1 1.580 0.880 – 2.837 0.126
 Histology grade, per grade 1.075 0.816 – 1.417 0.606
 Tumor number, per number 1.137 0.948 – 1.362 0.166
 Ascites yes = 1 1.566 0.751 – 3.265 0.231
 AFP, per ng/mL 1.032 1.011 – 1.054 0.003
 Albumin, per g/L 0.709 0.521 – 0.964 0.028
 AST, per U/L 1.002 0.998 – 1.006 0.257
 ALT, per U/L 1.000 0.997 – 1.003 0.999
  1. AFP alpha-fetoprotein, PT prothrombin time, AST aspartate aminotransferase, ALT alanine aminotransferase, HR hazard ratio, CI confidence interval; Values in bold, P < 0.05