Skip to main content

Advertisement

Table 2 Cox proportional hazard analysis for sex difference in relationship to intrahepatic recurrence-free survival in various clinical subgroups (Male = 1)

From: Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

   No. of patients HR 95% CI P
Overall   516 1.255 0.944 – 1.668 0.118
Age, years <58 262 1.448 0.912 – 2.298 0.117
≥58 254 1.162 0.801 – 1.685 0.430
Anti-HCV Negative 381 1.329 0.928 – 1.902 0.121
Positive 135 1.280 0.779 – 2.103 0.330
HBsAg Negative 157 1.591 0.983 – 2.575 0.059
Positive 359 1.118 0.783 – 1.598 0.539
Liver cirrhosis No 219 1.533 0.955 – 2.460 0.077
Yes 297 1.080 0.754 – 1.545 0.675
Microvascular invasion No 343 1.090 0.772 – 1.539 0.625
Yes 173 1.203 0.710 – 2.038 0.491
Macrovascular invasion No 449 1.283 0.943 – 1.747 0.113
Yes 67 0.939 0.442 – 1.996 0.870
Histology grade <3 233 1.477 0.938 – 2.327 0.092
≥3 283 1.123 0.778 – 1.621 0.534
Capsule No 141 1.328 0.766 – 2.303 0.312
Yes 375 1.219 0.873 – 1.700 0.245
Tumor number 1 306 1.170 0.806 – 1.697 0.409
>1 210 1.295 0.830 – 2.022 0.255
Ascites No 477 1.133 0.846 – 1.516 0.403
Yes 39 5.798 1.336 – 25.168 0.019
Alcoholism No 383 1.227 0.905 – 1.665 0.188
Yes 133 0.685 0.168 – 2.796 0.598
Largest tumor size, cm ≤4 242 1.176 0.784 – 1.764 0.434
>4 274 1.276 0.853 – 1.910 0.236
AFP, ng/mL ≤35 270 1.796 1.102 – 2.926 0.019
>35 246 1.085 0.760 – 1.550 0.653
Albumin, g/L ≤4 279 1.372 0.937 – 2.008 0.104
>4 237 1.139 0.741 – 1.752 0.552
Bilirubin, mg/dL ≤0.8 263 1.336 0.913 – 1.955 0.136
>0.8 253 1.100 0.713 – 1.696 0.668
PT, sec <12 259 1.200 0.797 – 1.808 0.382
≥12 257 1.264 0.848 – 1.885 0.250
PT, INR <1.1 270 1.230 0.819 – 1.846 0.319
≥1.1 246 1.261 0.844 – 1.884 0.258
Creatinine, mg/dL ≤1 294 1.256 0.906 – 1.739 0.171
>1 222 1.342 0.625 – 2.882 0.450
AST, U/L ≤39 262 1.351 0.865 – 2.110 0.186
>39 254 1.206 0.832 – 1.747 0.323
ALT, U/L ≤40 255 1.493 0.989 – 2.260 0.058
>40 261 0.988 0.667 – 1.464 0.954
  1. AFP alpha-fetoprotein, PT prothrombin time, INR international normalized ratio, AST aspartate aminotransferase, ALT alanine aminotransferase, HR hazard ratio, CI confidence interval; Values in bold, P < 0.05