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Table 5 Factors associated with postoperative mortality in patients with breast cancer after propensity score matching

From: Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study

Variables

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Dexamethasone

 No

1 (ref)

   

1 (ref)

   

 Yes

1.223

0.733

2.041

0.442

1.506

0.886

2.561

0.130

Age

1.005

0.983

1.028

0.636

    

Age (years)

 < 40

1 (ref)

   

1 (ref)

   

 40–49

0.607

0.331

1.113

0.107

0.979

0.517

1.855

0.949

 50–59

0.763

0.416

1.400

0.382

0.778

0.411

1.473

0.440

 60–69

1.165

0.574

2.364

0.673

0.962

0.419

2.208

0.927

 ≥70

1.087

0.318

3.714

0.894

0.866

0.226

3.323

0.834

BMI

0.991

0.925

1.063

0.810

    

BMI (kg m−2)

 < 18.4

0.852

0.542

3.358

0.520

0.759

0.179

3.216

0.709

 18.4–22.9

1 (ref)

   

1 (ref)

   

 23–24.9

1.449

0.765

1.757

0.485

1.647

0.994

2.730

0.053

 25–29.9

1.012

0.597

1.417

0.703

1.008

0.584

1.740

0.976

 ≥30

        

HTN

 No

1 (ref)

       

 Yes

1.692

1.052

2.723

0.030

    

DM

 No

1 (ref)

       

 Yes

1.775

0.858

3.672

0.122

    

Anaesthetic agents

 TIVA

1 (ref)

   

1 (ref)

   

 Volatile

1.050

0.258

4.272

0.946

1.400

0.332

5.892

0.647

N2O

 No

1 (ref)

       

 Yes

1.523

0.840

2.763

0.166

    

Transfusion

 No

1 (ref)

   

1 (ref)

   

 Yes

6.113

1.503

24.857

0.011

3.063

0.6900

13.600

0.141

Premedicationa

 No

1 (ref)

       

 Yes

0.796

0.515

1.231

0.305

    

Surgical procedure

 BCS

1 (ref)

   

1 (ref)

   

 Mastectomy

2.699

1.652

4.408

< 0.001

2.289

1.367

3.833

0.002

TNM staging

 1

1 (ref)

   

1 (ref)

   

 2

2.403

1.293

4.466

0.006

1.553

0.774

3.117

0.216

 3

8.587

4.770

15.458

< 0.001

5.509

2.732

11.106

< 0.001

Oestrogen receptor

 No

1 (ref)

   

1 (ref)

   

 Yes

0.338

0.222

0.514

< 0.001

0.699

0.374

1.305

0.261

Progesterone receptor

 No

1 (ref)

   

1 (ref)

   

 Yes

0.280

0.180

0.435

< 0.001

0.428

0.228

0.803

0.008

Chemotherapy

 No

1 (ref)

   

1 (ref)

   

 Yes

4.667

2.156

10.103

< 0.001

1.381

0.549

3.474

0.493

Radiotherapy

 No

1 (ref)

       

 Yes

1.473

0.926

2.343

0.102

    
  1. CI confidence interval, HR hazard ratio, BMI body mass index, HTN hypertension, DM diabetes mellitus, TIVA total intravenous anaesthesia, N2O nitrous oxide, BCS breast conserving surgery, TNM tumour-node-metastasis
  2. In 1 to 5 propensity matching process, the basic characteristics of 1224 subjects in the control group were considered to be different from the dexamethasone group and excluded from the final matching analyses. Consequently, 234 patients who received dexamethasone and 1170 patients who did not receive dexamethasone were included
  3. aPremedication: Midazolam 0.03 mg kg−1 was administered
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BMC Cancer

ISSN: 1471-2407

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