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Table 4 Univariate and multivariate Cox regression analyses of factors associated with mortality after surgery for breast cancer

From: Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study

Variables

Univariate

Multivariate

HR

95% CI

P-value

HR

95% CI

P-value

Dexamethasone

 No

1 (ref)

   

1 (ref)

   

 Yes

1.051

0.652

1.696

0.837

1.256

0.770

2.047

0.361

Age

1.028

1.013

1.042

< 0.001

    

Age (years)

 < 40

1 (ref)

   

1 (ref)

   

 40–49

0.586

0.369

0.931

0.024

0.772

0.480

1.240

0.285

 50–59

0.852

0.539

1.346

0.493

0.922

0.575

1.479

0.736

 60–69

1.175

0.716

1.929

0.523

1.151

0.654

2.027

0.625

 ≥70

2.713

1.534

4.798

< 0.001

2.427

1.220

4.830

0.012

BMI

0.993

0.947

1.041

0.758

    

BMI (kg m−2)

 < 18.4

1.564

0.810

3.021

0.183

1.271

0.653

2.474

0.480

 18.4–22.9

1 (ref)

   

1 (ref)

   

 23–24.9

1.14

0.788

1.649

0.488

1.180

0.813

1.715

0.384

 25–29.9

1.016

0.696

1.483

0.934

0.963

0.657

1.413

0.847

 ≥30

1.209

0.527

2.775

0.654

1.265

0.545

2.939

0.584

HTN

 No

1 (ref)

   

1 (ref)

   

 Yes

1.564

1.128

2.166

0.007

1.048

0.703

1.563

0.817

DM

 No

1 (ref)

   

1 (ref)

   

 Yes

1.810

1.148

2.852

0.0107

1.217

0.732

2.023

0.450

Anaesthetic agents

 TIVA

1 (ref)

   

1 (ref)

   

 Volatile

0.497

0.123

2.017

0.328

3.036

0.738

12.485

0.124

N2O

 No

1 (ref)

       

 Yes

1.388

0.892

2.158

0.146

    

Transfusion

 No

1 (ref)

   

1 (ref)

   

 Yes

7.527

2.792

20.296

< 0.001

5.551

1.980

15.559

0.001

Premedicationa

 No

1 (ref)

       

 Yes

0.817

0.602

1.108

0.193

    

Surgical procedure

 BCS

1 (ref)

   

1 (ref)

   

 Mastectomy

3.073

2.169

4.355

< 0.001

2.244

1.556

3.236

< 0.001

TNM staging

 1

        

 2

1.902

1.275

2.838

0.002

1.591

0.994

2.545

0.053

 3

6.312

4.318

9.226

< 0.001

5.435

3.338

8.850

< 0.001

Oestrogen receptor

 No

1 (ref)

   

1 (ref)

   

 Yes

0.398

0.297

0.533

< 0.001

0.758

0.488

1.177

0.217

Progesterone receptor

 No

1 (ref)

   

1 (ref)

   

 Yes

0.369

0.274

0.496

< 0.001

0.565

0.367

0.870

0.010

Chemotherapy

 No

1 (ref)

   

1 (ref)

   

 Yes

1.870

1.293

2.706

< 0.001

0.674

0.403

1.128

0.133

Radiotherapy

 No

1 (ref)

       

 Yes

0.922

0.682

1.246

0.597

    
  1. CI confidence interval, HR hazard ratio, BMI body mass index, HTN hypertension, DM diabetes mellitus, TIVA total intravenous anaesthesia, N2O nitrous oxide, BCS breast conserving surgery, TNM tumour-node-metastasis
  2. aPremedication: Midazolam 0.03 mg kg−1 was administered
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BMC Cancer

ISSN: 1471-2407

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