Fig. 10From: Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumorsHeterospheroids. The individual interstitial fluid pressures (PIF) in heterospheroids containing a mixture of mouse embryonic fibroblasts (MEFs) and MDA-MB-231 breast tumor cells (4:1) (a). α11-KO MEFs + MDA-MB-231 spheroids showed a significant reduction in PIF compared to WT MEFs + MDA-MB-231 spheroids. *** p < 0.001. Transmission electron microscopy images show collagen fibrils in both heterospheroid types (b)Back to article page